{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:36:14Z","timestamp":1773632174123,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":79,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["16.512.11.2281"],"award-info":[{"award-number":["16.512.11.2281"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["15-04-06571"],"award-info":[{"award-number":["15-04-06571"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Nitric oxide can successfully compete with oxygen for sites of electron\u2010transport chain in conditions of myocardial hypoxia. These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia\u2010reoxygenation. <jats:italic>Aim<\/jats:italic>. To study the action of the potent stable NO donor dinitrosyl iron complex with glutathione (Oxacom\u00ae) on the recovery of myocardial contractile function and Ca<jats:sup>2+<\/jats:sup> transients in cardiomyocytes during hypoxia\u2010reoxygenation. <jats:italic>Results<\/jats:italic>. The isolated rat hearts were subjected to 30\u2009min hypoxia followed by 30\u2009min reoxygenation. The presence of 30\u2009nM Oxacom in hypoxic perfusate reduced myocardial contracture and improved recovery of left ventricular developed pressure partly due to elimination of cardiac arrhythmias. The same Oxacom concentration limited reactive oxygen species generation in hypoxic cardiomyocytes and increased the viability of isolated cardiomyocytes during hypoxia from 12 to 52% and after reoxygenation from 0 to 40%. Oxacom prevented hypoxia\u2010induced elevation of diastolic Ca<jats:sup>2+<\/jats:sup> level and eliminated Ca<jats:sup>2+<\/jats:sup> transport alterations manifested by slow Ca<jats:sup>2+<\/jats:sup> removal from the sarcoplasm and delay in cardiomyocyte relaxation. <jats:italic>Conclusion<\/jats:italic>. The potent stable NO donor preserved cardiomyocyte integrity and improved functional recovery at hypoxia\u2010reoxygenation both in the isolated heart and in cardiomyocytes mainly due to preservation of Ca<jats:sup>2+<\/jats:sup> transport. Oxacom demonstrates potential for cardioprotection during hypoxia\u2010reoxygenation.<\/jats:p>","DOI":"10.1155\/2017\/9456163","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T23:07:42Z","timestamp":1490137662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart"],"prefix":"10.1155","volume":"2017","author":[{"given":"Valery I.","family":"Kapelko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir L.","family":"Lakomkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Abramov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena 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