{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:06:30Z","timestamp":1781244390347,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>To investigate the repeatability and safety of measuring impulse oscillation system (IOS) parameters and the point of wheezing during bronchoprovocation testing of preschool children.<jats:italic>Methods.<\/jats:italic>Two sets of methacholine challenge were conducted in 36 asthma children. The test was discontinued if there was a significant change in reactance (Xrs5) and resistance (Rrs5) at 5\u2009Hz (Condition 1) or respiratory distress due to airway obstruction (Condition 2). The repeatability of PC<jats:sub>80<\/jats:sub>_Xrs5, PC<jats:sub>30<\/jats:sub>_Rrs5, and wheezing (PCw) was assessed. The changes in<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>Z<\/mml:mi><\/mml:mrow><\/mml:math>-scores and SD-indexes from prebaseline (before testing) to postbaseline (after bronchodilator) were determined.<jats:italic>Results.<\/jats:italic>For PC<jats:sub>30<\/jats:sub>_Rrs5, PC<jats:sub>80<\/jats:sub>_Xrs5, and PCw for subjects, PC<jats:sub>80<\/jats:sub>_Xrs5 showed the highest repeatability. Fifteen of 70 tests met Condition<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><\/mml:mrow><\/mml:math>. The changes from pre- and postbaseline values varied significantly for Rrs5 and Xrs5. Excluding subjects with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>Z<\/mml:mi><\/mml:mrow><\/mml:math>-scores higher than 2SD, we were able to detect 97.1% of bronchial hyperresponsiveness during methacholine challenge based on the change in Rrs5 or Xrs5. A change in IOS parameters was associated with wheezing at all frequencies.<jats:italic>Conclusion<\/jats:italic>. Xrs5 and Rrs5 have repeatability comparable with FEV1, and Xrs5 is more reliable than Rrs5. Clinicians can safely perform a challenge test by measuring the changes in Rrs5, Xrs5, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>Z<\/mml:mi><\/mml:mrow><\/mml:math>-scores from the prebaseline values.<\/jats:p>","DOI":"10.1155\/2017\/9460190","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T17:03:23Z","timestamp":1498583003000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children"],"prefix":"10.1155","volume":"2017","author":[{"given":"Sun Hee","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Ho","family":"Sheen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHA 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