{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:22Z","timestamp":1787017702053,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PROGRES Q25\/LF1"],"award-info":[{"award-number":["PROGRES Q25\/LF1"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["RVO-VFN64165\/2017"],"award-info":[{"award-number":["RVO-VFN64165\/2017"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    The aim of our study was to assess the possible relationships among heme oxygenase (HMOX), bilirubin UDP\u2010glucuronosyl transferase (UGT1A1) promoter gene variations, serum bilirubin levels, and Fabry disease (FD). The study included 56 patients with FD (M\u2009:\u2009F ratio\u2009=\u20090.65) and 185 healthy individuals. Complete standard laboratory and clinical work\u2010up was performed on all subjects, together with the determination of total peroxyl radical\u2010scavenging capacity. The (GT)n and (TA)n dinucleotide variations in the\n                    <jats:italic>HMOX1<\/jats:italic>\n                    and\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    gene promoters, respectively, were determined by DNA fragment analysis. Compared to controls, patients with FD had substantially lower serum bilirubin levels (12.0 versus 8.85\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    mol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003) and also total antioxidant capacity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), which showed a close positive relationship with serum bilirubin levels (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.067) and the use of enzyme replacement therapy (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.036). There was no association between\n                    <jats:italic>HMOX1<\/jats:italic>\n                    gene promoter polymorphism and manifestation of FD. However, the presence of the TA\n                    <jats:sub>7<\/jats:sub>\n                    allele\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    gene promoter, responsible for higher systemic bilirubin levels, was associated with a twofold lower risk of manifestation of FD (OR\u2009=\u20090.51, 95% CI\u2009=\u20090.27\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.038). Markedly lower serum bilirubin levels in FD patients seem to be due to bilirubin consumption during increased oxidative stress, although\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    promoter gene polymorphism may modify the manifestation of FD as well.\n                  <\/jats:p>","DOI":"10.1155\/2017\/9478946","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T17:03:03Z","timestamp":1502902983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum Bilirubin Levels and Promoter Variations in\n                    <i>HMOX1<\/i>\n                    and\n                    <i>UGT1A1<\/i>\n                    Genes in Patients with Fabry Disease"],"prefix":"10.1155","volume":"2017","author":[{"given":"Alena","family":"Jir\u00e1skov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bortolussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Dost\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Eremi\u00e1\u0161ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubor","family":"Gola\u0148","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vil\u00e9m","family":"Danzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Linhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-0151","authenticated-orcid":false,"given":"Libor","family":"V\u00edtek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61589-5"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-30"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.10.003"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154550.15963.80"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0311-3"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0089-x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0794-0"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft104"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/504601"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67635-0"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2008.06.016"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2015.04.012"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.07.016"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.11.001"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.096352"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.520"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.07.017"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029864"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9748"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(06)43001-8"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00601-3"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.008"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.01.001"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161209789058237"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0253-6"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(00)00017-9"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.01.006"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140566"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20162"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2016.06.006"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000166000.24321.4F"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.051"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701991104"},{"key":"e_1_2_10_34_2","first-page":"244","article-title":"Unconjugated 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