{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:50Z","timestamp":1787017730551,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    The presence of vital bone after maxillary sinus augmentation is crucial to enhance the quality of bone-implant interface, ensuring predictable long-term results. The aims of this RCT with split-mouth design were the histologic and histomorphometric comparison of two different biomaterials in sinus elevation after 6 months of healing and the evaluation of the clinical outcomes of implants inserted in the augmented areas after 12 months of prosthetic loading. Twenty-eight patients (10 females, 18 males) were treated with bilateral sinus floor elevation with lateral approach. Pure sintered nanohydroxyapatite (NHA) and anorganic bovine bone (ABB) were used as test and active control, respectively. After six months, 52 bone biopsies were harvested from 26 patients, and 107 implants were inserted in the augmented areas. Histomorphometry showed that, in the two groups, vital bone percentages were\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mn fontstyle=\"italic\">34.9<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">15<\/mml:mn>\n                    <\/mml:math>\n                    % (NHA) and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mn fontstyle=\"italic\">38.5<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">17<\/mml:mn>\n                    <\/mml:math>\n                    % (ABB) (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.428<\/mml:mn>\n                    <\/mml:math>\n                    ), marrow spaces percentages were\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mn fontstyle=\"italic\">44.5<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">18<\/mml:mn>\n                    <\/mml:math>\n                    % (NHA) and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mn fontstyle=\"italic\">43.5<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">23<\/mml:mn>\n                    <\/mml:math>\n                    % (ABB) (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.866<\/mml:mn>\n                    <\/mml:math>\n                    ), and residual graft percentages were\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                      <mml:mn fontstyle=\"italic\">20.6<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">13<\/mml:mn>\n                    <\/mml:math>\n                    % (NHA) and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                      <mml:mn fontstyle=\"italic\">22.3<\/mml:mn>\n                      <mml:mo>\u00b1<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">12<\/mml:mn>\n                    <\/mml:math>\n                    % (ABB) (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.638<\/mml:mn>\n                    <\/mml:math>\n                    ). After 6 months of healing, no statistically significant difference was present in histomorphometric outcomes between NHA and ABB groups. Implant survival rate in NHA group after 12 months of loading was 96.4%, showing no statistically significant differences with ABB group.\n                  <\/jats:p>","DOI":"10.1155\/2017\/9489825","type":"journal-article","created":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T17:02:41Z","timestamp":1502038961000},"page":"1-10","source":"Crossref","is-referenced-by-count":31,"title":["Histologic and Histomorphometric Comparison between Sintered Nanohydroxyapatite and Anorganic Bovine Xenograft in Maxillary Sinus Grafting: A Split-Mouth Randomized Controlled Clinical Trial"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-4980","authenticated-orcid":true,"given":"Claudio","family":"Stacchi","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 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