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Salvianic acid A (SAA) is a renowned Traditional Chinese Medicine (TCM) that has been applied in the treatment of cardiovascular disease for many decades. In this study, we aimed (1) to investigate the CV protective effects of SAA on ameliorating LVH and ED in <jats:italic>db\/db<\/jats:italic> mice with elevated blood Hcy level and (2) to decipher whether the observed CV protective effects of SAA are associated with Hcy metabolism by modulating the methylation potential and redox status in the liver of the <jats:italic>db\/db<\/jats:italic> mice with elevated blood Hcy level. Our results found that the administration of SAA could significantly slow down the build\u2010up of left ventricular mass and ameliorate ED. Immunological assay analysis on the mouse liver tissue also indicated that SAA treatment on <jats:italic>db\/db<\/jats:italic> mice with elevated Hcy was associated with reduced methylation potential but improved redox status. In conclusion, we revealed that SAA has the potential to protect against the hyperglycemia\u2010 and hyperhomocysteinemia\u2010induced oxidative stress on diabetic mice via modulation in Hcy metabolism.<\/jats:p>","DOI":"10.1155\/2017\/9506925","type":"journal-article","created":{"date-parts":[[2017,9,17]],"date-time":"2017-09-17T21:01:53Z","timestamp":1505682113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular Protective Effects of Salvianic Acid A on <i>db\/db<\/i> Mice with Elevated Homocysteine Level"],"prefix":"10.1155","volume":"2017","author":[{"given":"Lei","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parco M.","family":"Siu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-wan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-7232","authenticated-orcid":false,"given":"Christopher W. 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