{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:44:36Z","timestamp":1778964276348,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of LUMHS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys native platelets. In this condition an autoantibody is generated against a platelet antigen. ITP affects women more often than men and is more common in children than adults.<jats:italic> Objective<\/jats:italic>. To assess the effect of<jats:italic> Helicobacter pylori<\/jats:italic> eradication therapy (HPET) on platelet count in<jats:italic> Helicobacter pylori<\/jats:italic> associated chronic immune thrombocytopenic purpura (chronic ITP) in adult.<jats:italic> Materials and Methods<\/jats:italic>. It is an interventional prospective study conducted at Liaquat University of Medical and Health Sciences, Jamshoro, from 2014 to 2015. A set of 85 patients diagnosed with chronic ITP were included in the study via convenient sampling. Patients with platelets count &lt; 100 <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo>\u00d7<\/mml:mo><\/mml:mrow><\/mml:math> 10<jats:sup>9<\/jats:sup>\/L for &gt;3 months were selected. They were posed to first-line investigations which comprised complete blood count (CBC) and peripheral blood smear examination followed by second-line tests including bone marrow examination and<jats:italic> Helicobacter pylori<\/jats:italic> stool specific antigen (HpSA-EIA). Standard<jats:italic> H. pylori<\/jats:italic> eradication therapy was offered and the patients were assessed at regular intervals for 6 months.<jats:italic> Results.<\/jats:italic> Of the 85 study patients, 32 (37.6%) were male and 53 (62.3%) were female. Mean ages of<jats:italic> H. pylori<\/jats:italic> positive and negative subjects were 43.89 \u00b1 7.06 and 44.75 \u00b1 7.91 years, respectively. Bone marrow examination confirmed the diagnosis and excluded other related BM disorders.<jats:italic> H. pylori<\/jats:italic> stool antigen (HpSA) was detected in 34 (40%) patients and hence regarded as<jats:italic> H. pylori<\/jats:italic> positive; the rest were negative. Treatment with eradication therapy significantly improved the mean platelet counts from <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">48.56<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">21.7<\/mml:mn><\/mml:math> \u00d7 10<jats:sup>9<\/jats:sup>\/l to <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">94.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">26.8<\/mml:mn><\/mml:math> \u00d7 10<jats:sup>9<\/jats:sup>\/l.<jats:italic> Conclusion.<\/jats:italic> We concluded that the<jats:italic> anti-H. pylori<\/jats:italic> eradication therapy improves blood platelet counts in chronic immune thrombocytopenia.<\/jats:p>","DOI":"10.1155\/2017\/9529752","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T17:37:57Z","timestamp":1484674677000},"page":"1-4","source":"Crossref","is-referenced-by-count":17,"title":["Role of<i> Helicobacter pylori<\/i> Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura"],"prefix":"10.1155","volume":"2017","author":[{"given":"Khan","family":"Sheema","sequence":"first","affiliation":[{"name":"Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-5929","authenticated-orcid":true,"given":"Ujjan","family":"Ikramdin","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naz","family":"Arshi","sequence":"additional","affiliation":[{"name":"National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naz","family":"Farah","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh","family":"Imran","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences, Jamshoro, 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