{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:14:41Z","timestamp":1762474481355,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>A small radiolucent area in the mandible was discovered in a 58\u2010year\u2010old woman with no oral complaints. The patient\u2019s history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Three months later, a CT revealed the presence of a cyst\u2010like lesion in the mandible with thin expanded buccal cortical plate, localized erosion, and a polylobate appearance on the lingual aspect of the cortical plate. The histological diagnosis of the lesion was central giant\u2010cell granuloma (CGCG). The lesion was thoroughly enucleated. Nevertheless, another X\u2010ray carried out six months later revealed multiple bilateral osteolytic areas throughout the jaw. In addition, widespread cortical plate erosion was observed, as well as signs of root resorption and periodontal enlargement. There was no sign of neurological involvement, although the nerves appeared to be dislocated. After full blood chemistry analysis and detailed collection of radiographs, the final diagnosis was brown tumors in primary hyperparathyroidism. This case report demonstrates how dental clinicians may be the first\u2010line specialists who identify a complex systemic disease before other clinicians. Finally, it highlights the role of cellular cannibalism in predicting the clinical aggressiveness of brown tumors as well as in other giant\u2010cell lesions.<\/jats:p>","DOI":"10.1155\/2017\/9604570","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T16:01:29Z","timestamp":1486656089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Giant\u2010Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and Review of Brown Tumors in Hyperparathyroidism"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-7651","authenticated-orcid":false,"given":"Lorenzo","family":"Azzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cimetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Annoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Tettamanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029x.180945"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.12.028"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.01.004"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-013-0552-1"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20539"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90119-3"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.92984"},{"key":"e_1_2_8_8_2","first-page":"731","article-title":"Langerhans cell histiocytosis mimicking aggressive periodontitis: challenges in diagnosis and management","volume":"47","author":"Panis V.","year":"2016","journal-title":"Quintessence International"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2013.43.2.117"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.5858\/133.11.1834"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.05.013"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.12.016"},{"key":"e_1_2_8_13_2","first-page":"16756","article-title":"Surgical treatment of polyostotic craniomaxillofacial fibrous dysplasia in adult: a case report and review of the literature","volume":"8","author":"Li J.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_14_2","first-page":"9718","article-title":"Giant cell rich osteosarcoma of the mandible with abundant spindle cells and osteoclast-like giant cells mimicking malignancy in giant cell tumor","volume":"8","author":"Sun L. M.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-013-0235-z"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0000000000000234"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.11.004"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-26-8-867"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4.437"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(53)90151-0"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12119"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12214"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.013"},{"key":"e_1_2_8_24_2","first-page":"15","article-title":"Cannibalism in a benign soft tissue tumor (giant-cell tumor of the tendon sheath, localized type): a study of 66 cases","volume":"53","author":"Fernandez-Flores A.","year":"2012","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"e_1_2_8_25_2","first-page":"774","article-title":"Subtraction scintigraphy with thallium-201 chloride and technetium-99m pertechnetate versus high resolution ultrasonography in the localization of the parathyroid glands in primary hyperparathyroidism","volume":"99","author":"Sim\u00f3n I.","year":"1992","journal-title":"Medicina Clinica"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0020011"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.52964\/AMJA.0455"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2017\/9604570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2017\/9604570.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/9604570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:10:35Z","timestamp":1762474235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/9604570"}},"subtitle":[],"editor":[{"given":"Junichi","family":"Asaumi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/9604570"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9604570","archive":["Portico"],"relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"type":"print","value":"2090-6447"},{"type":"electronic","value":"2090-6455"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9604570"}}