{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:56Z","timestamp":1774418456400,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Chlorhexidine is an antiseptic and disinfectant used in surgical and clinical practice since 1954 and is available in aqueous or alcoholic solutions 0.5%\u20134.0% and has a broad-spectrum activity. Despite their widespread use, allergic reactions with chlorhexidine are rarely reported. We describe a case of anaphylaxis with chlorhexidine during a septoplasty, turbinectomy, and maxillary sinusectomy. The patient presented with periorbital edema, hives, hypotension, and wheezing. Immediately after the diagnosis of anaphylaxis promethazine, hydrocortisone, and epinephrine were administered with immediate clinical improvement. This case highlights the importance of assessing whether there is a previous clinical history of hypersensitivity to chlorhexidine in patients who will undergo surgical procedures.<\/jats:p>","DOI":"10.1155\/2017\/9605804","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T17:02:06Z","timestamp":1489942926000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Perioperative Anaphylaxis to Chlorhexidine during Surgery and Septoplasty"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ana Paula","family":"Teixeira de Abreu","sequence":"first","affiliation":[{"name":"Hospital Evandro Ribeiro, Rua Catarina de Castro, 75 Morro da Gl\u00f3ria, 36036-060 Juiz de Fora, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Ramos","family":"Ribeiro de Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Evandro Ribeiro, Rua Catarina de Castro, 75 Morro da Gl\u00f3ria, 36036-060 Juiz de Fora, 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Monteiro","family":"Aarestrup","sequence":"additional","affiliation":[{"name":"Hospital Evandro Ribeiro, Rua Catarina de Castro, 75 Morro da Gl\u00f3ria, 36036-060 Juiz de Fora, MG, Brazil"},{"name":"Servi\u00e7o de Alergia e Imunologia Cl\u00ednica Hospital Maternidade Therezinha de Jesus e Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora (SUPREMA), Alameda Salvaterra, 200 Salvaterra, 36033-003 Juiz de Fora, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Fonseca","family":"Aarestrup","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Alergia e Imunologia Cl\u00ednica Hospital Maternidade Therezinha de Jesus e Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora (SUPREMA), Alameda Salvaterra, 200 Salvaterra, 36033-003 Juiz de Fora, MG, Brazil"},{"name":"Instituto de Ensino Superior Presidente Tancredo de Almeida Neves (IPTAN), Avenida Leite de Castro, 1101 F\u00e1bricas, 36301-182 S\u00e3o 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