{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T16:37:45Z","timestamp":1742402265644,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF RII-2FECOIA 1632891","BT\/PR7666\/MED\/30\/936\/2013"],"award-info":[{"award-number":["NSF RII-2FECOIA 1632891","BT\/PR7666\/MED\/30\/936\/2013"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DBT","award":["NSF RII-2FECOIA 1632891","BT\/PR7666\/MED\/30\/936\/2013"],"award-info":[{"award-number":["NSF RII-2FECOIA 1632891","BT\/PR7666\/MED\/30\/936\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Journal"],"published-print":{"date-parts":[[2017,12,13]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Studies have demonstrated the utility of closed-loop neuromodulation in treating focal onset seizures. There is an utmost need of neurostimulation therapy for generalized tonic-clonic seizures. The study goals are to map the thalamocortical network dynamics during the generalized convulsive seizures and identify targets for reliable seizure detection.<jats:italic> Methods<\/jats:italic>. Local field potentials were recorded from bilateral cortex, hippocampi, and centromedian thalami in Sprague-Dawley rats. Pentylenetetrazol was used to induce multiple convulsive seizures. The performances of two automated seizure detection methods (line length and P-operators) as a function of different cortical and subcortical structures were estimated. Multiple linear correlations-Granger\u2019s Causality was used to determine the effective connectivity.<jats:italic> Results<\/jats:italic>. Of the 29 generalized tonic-clonic seizures analyzed, line length detected 100% of seizures in all the channels while the P-operator detected only 35% of seizures. The detection latencies were shortest in the thalamus in comparison to the cortex. There was a decrease in amplitude correlation within the thalamocortical network during the seizure, and flow of information was decreased from thalamus to hippocampal-parietal nodes.<jats:italic> Significance<\/jats:italic>. The preclinical study confirms thalamus as a superior target for automated detection of generalized seizures and modulation of synchrony to increase coupling may be a strategy to abate seizures.<\/jats:p>","DOI":"10.1155\/2017\/9606213","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T23:31:51Z","timestamp":1513207911000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation"],"prefix":"10.1155","volume":"2017","author":[{"given":"Puneet","family":"Dheer","sequence":"first","affiliation":[{"name":"Systems Science and Informatics Unit, Indian Statistical Institute, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganne","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, NIMHANS, Bangalore 560029, 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