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The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. <jats:italic>Materials and Methods<\/jats:italic>. CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05\u2009\u00b1\u200912.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome. <jats:italic>Results<\/jats:italic>. Of the 36 lesions, 34 lesions (94.4%) reduced obviously with small cavitations or fibrous stripes formed and had no evidence of recurrence during follow-up. The volume of the other 2 lesions demonstrated local progression after 6 months by follow-up CT. The primary complications included pneumothorax (28%), chest pain (21%), and fever (5%). These symptoms and signs were obviously relieved or disappeared after several-day conservative treatment. The mean follow-up of the patients was 25.54\u2009\u00b1\u200912.58 months (range 2\u201341 months). The estimated progression-free survival rate was 94.4%. <jats:italic>Conclusion<\/jats:italic>. Our results demonstrate that CT-guided percutaneous MWA appears to be an effective, reliable, and minimally invasive method for the treatment of lung metastasis from colorectal cancer. This trial is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=22031\">ChiCTR-ORC-17012904<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2017\/9621585","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T19:32:45Z","timestamp":1509478365000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Application of CT-Guided Percutaneous Microwave Ablation for the Treatment of Lung Metastasis from Colorectal Cancer"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-758X","authenticated-orcid":true,"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, 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