{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:39:27Z","timestamp":1785368367500,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Natural Science Project of Anhui Province","award":["KJ2016A472"],"award-info":[{"award-number":["KJ2016A472"]}]},{"name":"University Natural Science Project of Anhui Province","award":["2016-40"],"award-info":[{"award-number":["2016-40"]}]},{"name":"Scientific Research Innovation Team Project of Anhui Colleges and Universities","award":["KJ2016A472"],"award-info":[{"award-number":["KJ2016A472"]}]},{"name":"Scientific Research Innovation Team Project of Anhui Colleges and Universities","award":["2016-40"],"award-info":[{"award-number":["2016-40"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore, to derive a more precise estimation of the association, a meta-analysis was performed. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of association between HLA-DQ polymorphism (rs2856718 and rs7453920) and HBV infection risk. A total of 11 articles were used to evaluate the effect of the two polymorphisms on risk of HBV infection. The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection. The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers; further investigation on a large population and different ethnicities is warranted.<\/jats:p>","DOI":"10.1155\/2017\/9679843","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T17:00:30Z","timestamp":1492966830000},"page":"1-11","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection"],"prefix":"10.1155","volume":"2017","author":[{"given":"Tao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, China"},{"name":"Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Bengbu Medical College, Bengbu, Anhui 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-7828","authenticated-orcid":true,"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Bengbu Medical College, Bengbu, Anhui 233030, China"},{"name":"Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00487.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0808185"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2013.00030"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra031087"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i12.1770"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.09.032"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24799"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr301"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010693"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2809"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080445"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12159"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111677"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12643"},{"issue":"3","key":"16","first-page":"384","volume":"37","year":"2016","journal-title":"Chinese Journal of Epidemiology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5077-z"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13405"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/srep14933"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9069375"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.11"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.02.005"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/9679843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/9679843.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/9679843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T17:00:35Z","timestamp":1492966835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/9679843\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"alternative-id":["9679843","9679843"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9679843","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}