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An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects. We established a rat epilepsy model by injecting kainic acid (KA, 12\u2009mg\/kg, i.p.) and subsequently investigated the effect of <jats:italic>Uncaria rhynchophylla<\/jats:italic> (UR) and its underlying mechanisms. Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures. Following KA injection, S100B levels increased in the hippocampus. This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250\u2009mg\/kg). Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins. Rats with KA\u2010induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation. Our results provide novel and detailed mechanisms, explaining the role of UR in KA\u2010induced epileptic seizures in hippocampal CA1 neurons.<\/jats:p>","DOI":"10.1155\/2017\/9732854","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:38:49Z","timestamp":1487893129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Long\u2010Term Intake of <i>Uncaria rhynchophylla<\/i> Reduces S100B and RAGE Protein Levels in Kainic Acid\u2010Induced Epileptic Seizures 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