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In present work, a surface plasmon resonance (SPR) assay confirms the direct binding between ZYZ\u2010488 and Apaf\u20101 and this interaction was found to be able to block the recruitment of procaspase\u20109 by Apaf\u20101. This study also shows that the treatment of MI (myocardial infarction) mice with this novel Apaf\u20101 inhibitor remarkably reduces the infarct size, improves cardiac functions, and attenuates the histopathology changes caused by MI. Meanwhile, here it is shown that ZYZ\u2010488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases. Moreover, in silico prediction validated the drug\u2010like properties of ZYZ\u2010488. In conclusion, our findings present the first piece of evidence indicating the interaction between Apaf\u20101 and procaspase\u20109 as a novel therapeutic target in myocardial infarction and suggesting ZYZ\u2010488 as a promising therapeutic option for myocardial infarction disease.<\/jats:p>","DOI":"10.1155\/2017\/9747296","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T23:34:27Z","timestamp":1511825667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Apoptotic Protease Activating Factor\u20101 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase\u20109 Recruitment by 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