{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:53:43Z","timestamp":1789995223912,"version":"4.0.1"},"reference-count":207,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Southern Iron Disorders Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in<jats:italic>HFE<\/jats:italic>hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in<jats:italic>HFE<\/jats:italic>hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons with<jats:italic>HFE<\/jats:italic>hemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without<jats:italic>HFE<\/jats:italic>hemochromatosis is similar. Routine iron phenotyping or<jats:italic>HFE<\/jats:italic>genotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes in<jats:italic>HFE<\/jats:italic>hemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and without<jats:italic>HFE<\/jats:italic>hemochromatosis.<\/jats:p>","DOI":"10.1155\/2017\/9826930","type":"journal-article","created":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T21:01:30Z","timestamp":1488142890000},"page":"1-16","source":"Crossref","is-referenced-by-count":54,"title":["Diabetes in<i>HFE<\/i>Hemochromatosis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-8276","authenticated-orcid":true,"given":"James C.","family":"Barton","sequence":"first","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, AL 35209, USA"},{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T.","family":"Acton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center, Birmingham, AL 35209, USA"},{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0200-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.05.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200011233432104"},{"key":"4","first-page":"663","volume":"2","year":"1865","journal-title":"Clinique M\u00e9dicale de l'H\u00f4tel-Dieu de Paris"},{"key":"5","first-page":"231","volume":"44","year":"1871","journal-title":"Bulletins de la Soci\u00e9t\u00e9 Anatomique de Paris"},{"key":"6","first-page":"324","volume":"62","year":"1889","journal-title":"Tagebl Versamml Natur \u00c4rtze Heidelberg"},{"key":"7","first-page":"1","volume-title":"History of iron overload disorders","year":"2010"},{"key":"8","year":"1935"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005792-195512000-00001","volume":"34","year":"1955","journal-title":"Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0713"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb01688.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805263182103"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2005.9.231"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261875"},{"key":"16","first-page":"65","volume-title":"Complications of hemochromatosis and iron overload","year":"2010"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.4.275"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jhep.2010.03.001","volume":"53","year":"2010","journal-title":"Journal of Hepatology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.10.009"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041534"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3252"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2842"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.01.014"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.018"},{"key":"25","first-page":"662","volume-title":"Hemochromatosis","year":"2014"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27711"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1172\/jci102639"},{"key":"28","first-page":"35","volume-title":"Indicators of the iron status of populations: ferritin","year":"2007"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.21.1.35"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197405302902201"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.010"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2337\/diab.5.2.98"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/BF01788899"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.539"},{"issue":"4","key":"35","first-page":"1095","volume":"18","year":"2003","journal-title":"Histology and Histopathology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.072314"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524356"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.03.011"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606424103"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.002"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0528"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90070-8"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2492"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051630898"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-014-0443-1"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.021"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0392"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1958.tb01765.x"},{"issue":"3","key":"49","first-page":"191","volume":"1","year":"1975","journal-title":"Diabete et Metabolisme"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300416"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1089\/met.2015.0123"},{"issue":"7525","key":"52","first-page":"1051","volume":"2","year":"1967","journal-title":"Lancet"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197401312900502"},{"issue":"1","key":"54","first-page":"53","volume":"16","year":"1968","journal-title":"Pathologie Biologie"},{"issue":"49","key":"55","first-page":"1841","volume":"107","year":"1977","journal-title":"Schweizerische Medizinische Wochenschrift"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/BF01234504"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1136\/gut.20.3.200"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-3-412"},{"issue":"6","key":"59","first-page":"351","volume":"71","year":"1987","journal-title":"South African Medical Journal"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(79)90171-9"},{"issue":"4","key":"61","first-page":"R445","volume":"244","year":"1983","journal-title":"The American Journal of Physiology"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90479-5"},{"key":"63","first-page":"197","volume-title":"Chromium","year":"2001"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.11.001"},{"key":"65","volume":"3, article 235","year":"2014","journal-title":"Advanced Biomedical Research"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9858-6"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24033"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m112.364208"},{"issue":"17","key":"69","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1016\/S0021-9258(18)93670-7","volume":"244","year":"1969","journal-title":"Journal of Biological Chemistry"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1021\/bi00622a033"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)90426-1"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-5-199803010-00005"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-1592"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1089\/met.2014.0106"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.11.024"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.12.1978"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-0631"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12529"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2506"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1159\/000057632"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.3.426"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.6.711"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00985.x"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2633-y"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114514002852"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0646-3"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2394"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.727"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2711"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0257"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.11.032"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.8.2061"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1081\/erc-100107172"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.5.532"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.08.003"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1002\/stem.150291"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.106456"},{"issue":"3","key":"98","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood.V48.3.449.449","volume":"48","year":"1976","journal-title":"Blood"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.3109\/10408367809150919"},{"key":"100","first-page":"588","volume":"35","year":"1956","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090103"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541155"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1007\/BF02934136"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4889(00)00066-5"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1991.tb05196.x"},{"issue":"9120","key":"106","first-page":"1933","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.525"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.104464"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.7.1187"},{"key":"110","volume":"4","year":"2016","journal-title":"BMJ Open Diabetes Research & Care"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3567"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.07.009"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1999.0240"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(99)70505-6"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/907356"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-14-74"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0702"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-013-0543-1"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1203"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20839"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262217"},{"issue":"2","key":"122","first-page":"110","volume":"20","year":"1997","journal-title":"Clinical and Investigative Medicine"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01238.x"},{"key":"124","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.2337\/dc14-2461","volume":"38","year":"2015","journal-title":"Diabetes Care"},{"key":"125","first-page":"239","volume-title":"Epidemiology and genetics of insulin dependent diabetes mellitus in the white and black population from the southeastern United States","year":"1981"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1038\/ng.381"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/453046"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(01)06526-6"},{"issue":"9","key":"129","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ng.2383","volume":"44","year":"2012","journal-title":"Nature Genetics"},{"issue":"3","key":"130","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ajhg.2011.12.022","volume":"90","year":"2012","journal-title":"American Journal of Human Genetics"},{"key":"131","first-page":"2245","volume":"45","year":"1967","journal-title":"Presse M\u00e9dicale"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22460"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202800"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13108"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21260"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602619"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22506"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.035"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198511143132004"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90013-B"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1198"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_part_2-199812011-00005"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1000"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90204-6"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.4236\/jdm.2015.53020"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-3082"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_part_2-199812011-00003"},{"issue":"3","key":"148","first-page":"40N","volume":"87","year":"1989","journal-title":"American Journal of Medicine"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.5.1176"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1086\/314554"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e31819069c1"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e3181eeda2c"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb55507.x"},{"key":"154","first-page":"268","volume-title":"Diabetes mellitus and hemochromatosis","year":"2000"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0445-7"},{"key":"156","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.06.005"},{"issue":"12","key":"157","volume":"21","year":"1998","journal-title":"Diabetes Care"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.046847"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-54"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.08.023"},{"issue":"1","key":"161","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ajcn\/79.1.70","volume":"79","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.12.009"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1086\/520001"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.01.007"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu076"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0473"},{"issue":"168","key":"167","first-page":"733","volume":"42","year":"1973","journal-title":"Quarterly Journal of Medicine"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2554-7_31"},{"issue":"1","key":"169","first-page":"34","volume":"59","year":"1980","journal-title":"Medicine (United States)"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1080\/00365520212510"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)07447-0"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa073286"},{"issue":"4","key":"173","first-page":"385","volume":"38","year":"1991","journal-title":"Danish Medical Bulletin"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150417"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613000"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-2-199707150-00002"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00276-3"},{"key":"178","first-page":"315","volume-title":"Estimate of the frequency of morbid complications of hemochromatosis","year":"2000"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750422747"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.3.294"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.3.401"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.26.10.770"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1017\/cbo9780511777035"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1080\/1024533032000158832"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198212303072703"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0583"},{"key":"187","first-page":"5","volume":"2004","year":"2004","journal-title":"Neurology & Clinical Neurophysiology"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.1.r99jl35227"},{"issue":"9","key":"189","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood.V75.9.1870.1870","volume":"75","year":"1990","journal-title":"Blood"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3071"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02599.x"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0646"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1899"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0365-0"},{"key":"195","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00022.2010"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00033.2011"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.016"},{"key":"198","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0593"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066570"},{"issue":"19","key":"200","doi-asserted-by":"crossref","first-page":"8708","DOI":"10.1016\/S0021-9258(19)84438-1","volume":"261","year":"1986","journal-title":"Journal of Biological Chemistry"},{"key":"201","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1602"},{"key":"202","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81860"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44421"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0505"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1581"},{"issue":"5","key":"206","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/ajcn\/86.5.1347","volume":"86","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.635"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2017\/9826930.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2017\/9826930.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2017\/9826930.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T20:33:15Z","timestamp":1658694795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jdr\/2017\/9826930\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":207,"alternative-id":["9826930","9826930"],"URL":"https:\/\/doi.org\/10.1155\/2017\/9826930","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}