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In our work, rats were divided into 4 groups of 8 animals each: control groups (C2, C4) and diabetic groups (STZ2, STZ4). The secretory function of salivary glands\u2014nonstimulated and stimulated salivary flow,<jats:italic>\u03b1<\/jats:italic>-amylase, total protein\u2014and salivary exoglycosidase activities\u2014N-acetyl-<jats:italic>\u03b2<\/jats:italic>-hexosaminidase (HEX, HEX A, and HEX B),<jats:italic>\u03b2<\/jats:italic>-glucuronidase,<jats:italic>\u03b1<\/jats:italic>-fucosidase,<jats:italic>\u03b2<\/jats:italic>-galactosidase, and<jats:italic>\u03b1<\/jats:italic>-mannosidase\u2014was estimated both in the parotid and submandibular glands of STZ-diabetic and control rats. The study has demonstrated that the activity of most salivary exoglycosidases is significantly higher in the parotid and submandibular glands of STZ-diabetic rats as compared to the healthy controls and that it increases as the disease progresses. Reduced secretory function of diabetic salivary glands was also observed. A significant inverse correlation between HEX B,<jats:italic>\u03b1<\/jats:italic>-amylase activity, and stimulated salivary flow in diabetic parotid gland has also been shown. Summarizing, STZ-induced diabetes leads to a change in the lysosomal exoglycosidase profile and reduced function of the salivary glands.<\/jats:p>","DOI":"10.1155\/2017\/9850398","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T23:34:21Z","timestamp":1514763261000},"page":"1-13","source":"Crossref","is-referenced-by-count":27,"title":["Lysosomal Exoglycosidase Profile and Secretory Function in the Salivary Glands of Rats with Streptozotocin-Induced Diabetes"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-3187","authenticated-orcid":true,"given":"Mateusz","family":"Maciejczyk","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kossakowska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Medical University of Bialystok, 24a M. 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