{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:30:04Z","timestamp":1781577004234,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> To investigate whether PPIs BID is superior to QD for treatment of GERD in a short time. <jats:italic>Methods.<\/jats:italic> We searched PubMed, Cochrane Library, Scopus, EMBASE, Ovid, EBSCO, and Web of Science databases (from 1998 to May 2016) to select RCTs, which compared the efficacy of PPIs BID versus QD for GERD. The primary outcomes were symptom relief or esophageal mucosal healing at weeks 4 and 8. The M-H method with fixed-effect or random-effect model was used to calculate RR and 95% CIs. <jats:italic>Results.<\/jats:italic> Seven RCTs were enrolled. The esophageal healing rates were higher in PPIs BID group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), and rabeprazole 20\u2009mg BID can achieve better mucosal healing than 20\u2009mg QD after 8 weeks (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). However, no significant differences were observed in heartburn relief (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.27<\/mml:mn><\/mml:math>), sustained symptom relief rates at week 4 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), 24\u2009h pH monitoring after treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.11<\/mml:mn><\/mml:math>), endoscopic response at week 4 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.22<\/mml:mn><\/mml:math>), and adverse events (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.18<\/mml:mn><\/mml:math>). <jats:italic>Conclusion.<\/jats:italic> PPIs BID more effectively improve endoscopic healing rate at week 8 than PPIs QD. But there are no significant differences in symptom relief, 24\u2009h pH monitoring, sustained symptom relief, and endoscopic response at week 4.<\/jats:p>","DOI":"10.1155\/2017\/9865963","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T17:02:04Z","timestamp":1503421324000},"page":"1-8","source":"Crossref","is-referenced-by-count":24,"title":["A Meta-Analysis and Systematic Review of the Efficacy of Twice Daily PPIs versus Once Daily for Treatment of Gastroesophageal Reflux Disease"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0702-1539","authenticated-orcid":true,"given":"Hongying","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"},{"name":"Department of Intensive Care Unit, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, Shaanxi 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