{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:45:39Z","timestamp":1790606739571,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alexandria University Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    This study was aimed at evaluating the efficacy of berberine\u2010rich fraction (BF) as a protective and\/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague\u2010Dawley male rats were divided into five groups treated with either corn oil, BF (100\u2009mg\/kg BW, orally, daily for 30 days), gossypol acetate (5\u2009mg\/kg BW, i.p.) eight times for 16 days, BF alone for 14 days then coadministered with gossypol acetate for the next 16 days (protected group), or gossypol acetate for 16 days then treated with BF for 30 days (treated group). All animals completed the experimental period (46 days) without obtaining any treatments in the gap period. Sperm parameters, oxidative index, and inflammatory markers were measured. Gossypol injection significantly decreased the semen quality and testosterone level that resulted from the elevation of testicular reactive oxygen and nitrogen species (TBARS and NO), TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010converting enzyme, and interleukins (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , IL\u20106, and IL\u201018) by 230, 180, 12.5, 97.9, and 300%, respectively, while interleukin\u201012 and tissue inhibitors of metalloproteinases\u20103 were significantly decreased by 59 and 66%, respectively. BF (protected and treated groups) significantly improved the semen quality, oxidative stress, and inflammation associated with male infertility. It is suitable to use more advanced studies to validate these findings.\n                  <\/jats:p>","DOI":"10.1155\/2018\/1056173","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T19:30:41Z","timestamp":1522783841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Ameliorating Effect of Berberine\u2010Rich Fraction against Gossypol\u2010Induced Testicular Inflammation and Oxidative Stress"],"prefix":"10.1155","volume":"2018","author":[{"given":"Samar R.","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-4377","authenticated-orcid":false,"given":"Doaa A.","family":"Ghareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.69"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2015.54596"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3335-4_1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2014.07.001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases5010009"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2017.58.6.385"},{"key":"e_1_2_7_8_2","first-page":"123","article-title":"Impact of inflammation on male reproductive tract","volume":"16","author":"Azenabor A.","year":"2015","journal-title":"Journal of Reproduction & Infertility"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2014.32.1.1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2741\/e223"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1998.tb02009.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01538-7"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.060"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90641.2008"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00177"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5693"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2017.8690"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9520-y"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.060"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.02.041"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/905749"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.09.002"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/289264"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.08.003"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.05.043"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-218"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/231635"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-015-0026-7"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1981.tb00615.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-4894-5_11"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.179.167"},{"key":"e_1_2_7_33_2","first-page":"724","article-title":"Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies","volume":"28","author":"Nair I. 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