{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:31:56Z","timestamp":1789014716224,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HB16C0075"],"award-info":[{"award-number":["HB16C0075"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic> We aimed to summarize and critically evaluate the available evidence regarding the efficacy and safety of acupuncture for children with autism spectrum disorder (ASD). <jats:italic>Methods.<\/jats:italic> We searched 13 databases for studies published up to December 2016. Randomized controlled trials (RCTs) evaluating the efficacy of acupuncture for children with ASD were included. Outcome measures were the overall scores on scales evaluating the core symptoms of ASD and the scores for each symptom, such as social communication ability and skills, stereotypies, language ability, and cognitive function. Effect sizes were presented as mean differences (MD). <jats:italic>Results.<\/jats:italic> Twenty\u2010seven RCTs with 1736 participants were included. Acupuncture complementary to behavioral and educational intervention significantly decreased the overall scores on the Childhood Autism Rating Scale (CARS) (MD \u22128.10, 95% CI \u221212.80 to \u22123.40) and the Autism Behavior Checklist (MD \u22128.92, 95% CI \u221211.29 to \u22126.54); however, it was unclear which of the ASD symptoms improved. Acupuncture as a monotherapy also reduced the overall CARS score. The reported adverse events were acceptable. <jats:italic>Conclusions.<\/jats:italic> This review suggests that acupuncture may be effective and safe for pediatric ASD. However, it is not conclusive due to the heterogeneity of the acupuncture treatment methods used in the studies.<\/jats:p>","DOI":"10.1155\/2018\/1057539","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T23:30:25Z","timestamp":1515713425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Efficacy and Safety of Acupuncture for the Treatment of Children with Autism Spectrum Disorder: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1679-0644","authenticated-orcid":false,"given":"Boram","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-5334","authenticated-orcid":false,"given":"Jihong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-1128","authenticated-orcid":false,"given":"Jin-Hong","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-1707","authenticated-orcid":false,"given":"Hyun-Kyung","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-3298","authenticated-orcid":false,"given":"Gyu Tae","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e31819e7203"},{"key":"e_1_2_9_3_2","first-page":"1","article-title":"Estimated Prevalence of Autism and Other Developmental Disabilities Following Questionnaire Changes in the 2014 National Health Interview Survey","author":"Zablotsky B.","year":"2015","journal-title":"National Health Statistics Reports"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2008.11.002"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa013171"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1352\/2009.114:23-41"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.01.008"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.012"},{"key":"e_1_2_9_9_2","unstructured":"NCCIH Publication No. D347 Complementary Alternative or Integrative Health: What\u2019s In a Name? 2016 https:\/\/nccih.nih.gov\/health\/integrative-health."},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2015.05.002"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2015.12.004"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0192-0"},{"key":"e_1_2_9_13_2","first-page":"42","article-title":"Trends in use of complementary and alternative medicine by us adults: 1997\u20132002","volume":"11","author":"Tindle H. 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