{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:22:39Z","timestamp":1783189359394,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Allergic contact dermatitis (ACD) is a common irritability skin disease, which can be cured by using the Chinese patent medicine. To explore the pharmacological effect of total flavonoids of Fructus Kochiae (FK) on ACD, we used dinitrochlorobenzene\u2010 (DNCB\u2010) induced ACD rats. Five groups were used in our experiments. The normal group and the DNCB group were treated with 0.5% CMC\u2010Na; the DNCB + hFK group was treated with a high dose of total flavonoids of FK (200\u2009mg\/kg); the DNCB + lFK group was treated with a low dose of FK (100\u2009mg\/kg); the DNCB + Pre group was treated with prednisolone acetate (2.5\u2009mg\/kg). The results showed that FK treatment had significantly attenuated the inflammation induced by DNCB. The increased concentration of cytokines including IL\u20106, IL\u201018, and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in ACD rats could be reversed by the FK administration, while IL\u201010 expressed the opposite result; the expression level of TLR4, pERK<jats:sub>1\/2<\/jats:sub>, and NF\u2010<jats:italic>\u03ba<\/jats:italic>B could be downregulated by the treatment with FK in the ACD rat. In a word, the total flavonoids of the FK had an anti\u2010inflammatory effect on the DNCB\u2010induced ACD rat; this regulatory mechanism was highly possible based on the pERK<jats:sub>1\/2<\/jats:sub>\/TLR4\u2010NF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway activation.<\/jats:p>","DOI":"10.1155\/2018\/1096920","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T23:30:21Z","timestamp":1515108621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Anti\u2010Inflammatory Effect of Fructus Kochiae on Allergic Contact Dermatitis Rats via pERK1\/2\/TLR4\/NF\u2010<i>\u03ba<\/i>B Pathway 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