{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:50:40Z","timestamp":1780635040038,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2005C00092"],"award-info":[{"award-number":["2005C00092"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2018,10,28]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. <jats:italic>Objective.<\/jats:italic> This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. <jats:italic>Results.<\/jats:italic> The severely ulcerated gastric mucosa of model rats had lower GSH-Px (52.21\u2009\u00b1\u20097.13) and SOD (7.03\u2009\u00b1\u20090.10) activity, and higher MDA (2.39\u2009\u00b1\u20090.03) content compared to sham rats. BA-Zn reduced the gastric ulcer index in a dose-dependent manner, significantly increased SOD activity and GSH-Px level, and reduced the MDA content and IL-8 and TNF-<jats:italic>\u03b1<\/jats:italic> levels in the gastric mucosa. BA-Zn (6.5 and 13\u2009mg\/kg) exerted a greater antiulcerogenic effect than both BA and zinc-gluconate, leading to a reduced ulcer index (18.43\u2009\u00b1\u20091.11, 15.00\u2009\u00b1\u20091.44), decreased MDA content (1.33\u2009\u00b1\u20090.07, 0.63\u2009\u00b1\u20090.01), and increased SOD activity (17.62\u2009\u00b1\u20090.11, 20.12\u2009\u00b1\u20090.32) and GSH-Px levels (102.12\u2009\u00b1\u20099.11, 120.25\u2009\u00b1\u20099.07). In addition, our results from Western blot suggested that BA-Zn (6.5 and 13\u2009mg\/kg) has a greater antiulcerogenic effect than both BA and zinc-gluconate. <jats:italic>Conclusion<\/jats:italic>. The BA-Zn complex possesses greater antichronic gastric ulcer properties compared to BA and zinc-gluconate due to its ability of oxidation resistance and anti-inflammatory effects.<\/jats:p>","DOI":"10.1155\/2018\/1275486","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T19:30:34Z","timestamp":1540755034000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Antichronic Gastric Ulcer Effect of Zinc-Baicalin Complex on the Acetic Acid-Induced Chronic Gastric Ulcer Rat Model"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-7838","authenticated-orcid":true,"given":"Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Biomedical Engineering Center, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Neurosurgery, The 1st Affiliated Hospital of Kunming 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