{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:00:21Z","timestamp":1781884821764,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1A2B3003856"],"award-info":[{"award-number":["2017R1A2B3003856"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A2B3003856"],"award-info":[{"award-number":["2017R1A2B3003856"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sensors"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>A microfluidic biosensor is proposed using a microwave substrate-integrated waveguide (SIW) cavity resonator. The main objectives of this noninvasive biosensor are to detect and analyze biomaterial using tiny liquid volumes (3\u2009<jats:italic>\u03bc<\/jats:italic>L). The sensing mechanism of our proposed biosensor relies on the dielectric perturbation phenomenon of biomaterial under test, which causes a change in resonance frequency and return loss (amplitude). First, an SIW cavity is realized on a Rogers RT\/Duroid 5870 substrate. Then, a microwell made from polydimethylsiloxane (PDMS) material is loaded on the SIW cavity to observe the perturbation phenomenon. The microwell is filled with phosphate-buffered saline (PBS) solution (reference biological medium). To demonstrate the sensing behavior, the fibroblast (FB) cells from the lungs of a human male subject are analyzed and one-port S-parameters are measured. The resonance frequency of the structure with FB cells is observed to be 13.48\u2009GHz. The reproducibility and repeatability of our proposed biosensor are successfully demonstrated through full-wave simulations and measurements. The resonance frequency of the FB-loaded microwell showed a shift of 170\u2009MHz and 20\u2009MHz, when compared to those of empty and PBS-loaded microwells. Its analytical limit of detection is 213 cells\/<jats:italic>\u03bc<\/jats:italic>L. Our proposed biosensor is noncontact and reliable. Furthermore, it is miniaturized, inexpensive, and fabricated using simple- and easy-design processes.<\/jats:p>","DOI":"10.1155\/2018\/1324145","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T23:30:51Z","timestamp":1517527851000},"page":"1-13","source":"Crossref","is-referenced-by-count":52,"title":["Microfluidic Biosensor Based on Microwave Substrate-Integrated Waveguide Cavity Resonator"],"prefix":"10.1155","volume":"2018","author":[{"given":"Ahmed","family":"Salim","sequence":"first","affiliation":[{"name":"School of Electrical and Electronics Engineering, College of Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, College of Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Yull","family":"Park","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, College of Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5049-9300","authenticated-orcid":true,"given":"Sungjoon","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronics Engineering, College of Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of 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