{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:31:01Z","timestamp":1762324261062,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":121,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Oxidative stress is a factor involved in the pathogenesis of celiac disease (CD), possibly affecting the course of the disease and celiac\u2010related complications. We assessed the intensity of oxidative processes and the efficiency of antioxidant defense in children with celiac disease<jats:italic>. Methods<\/jats:italic>. Group I (<jats:italic>n<\/jats:italic> = 32) consisted of children with CD treated with a gluten\u2010free diet, and group II (<jats:italic>n<\/jats:italic> = 24) consisted of healthy children on a traditional diet. Antioxidative and oxidative status was assessed by measurement of serum total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidized low\u2010density lipoprotein (ox\u2010LDL) and on the basis of oxidative stress index (OSI). <jats:italic>Results<\/jats:italic>. There were no significant differences in serum TAC, TOC, ox\u2010LDL, and OSI between children with CD and healthy children. Cluster analysis showed that the group of children with CD is not homogeneous in terms of serum TAC and TOC levels. About 50% of these children had TAC levels\u2009&lt;\u20091.3\u2009mmol\/L and TOC levels\u2009&gt;\u20090.35\u2009mmol\/L. <jats:italic>Conclusions<\/jats:italic>. Strict adherence to a gluten\u2010free diet by children with CD seems to be important for maintaining oxidative\u2010antioxidant balance. However, further research is needed to identify factors potentially responsible for increased oxidative stress in some children with celiac disease despite adherence to a gluten\u2010free diet.<\/jats:p>","DOI":"10.1155\/2018\/1324820","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T23:31:10Z","timestamp":1525303870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oxidative and Antioxidative Status of Children with Celiac Disease Treated with a Gluten 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