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Our previous studies have showed that \u0394<jats:sup>3<\/jats:sup>,2\u2010hydroxybakuchiol inhibited the decreased activity of reserpinized mice, suggestive of its antidepressive potential. In this study, we explored the antidepressant profile of \u0394<jats:sup>3<\/jats:sup>,2\u2010hydroxybakuchiol in various rodent models and its possible monoamine\u2010modulating mechanism. \u0394<jats:sup>3<\/jats:sup>,2\u2010Hydroxybakuchiol significantly reduced immobility time of mice in forced swim test and tail suspension test. \u0394<jats:sup>3<\/jats:sup>,2\u2010Hydroxybakuchiol also significantly increased sucrose consumption in chronic unpredictable mild stress (CUMS) rat model. Furthermore, isotope uptake study showed that \u0394<jats:sup>3<\/jats:sup>,2\u2010hydroxybakuchiol inhibited the activity of human dopamine transporter (DAT) and norepinephrine transporter (NET) in transporter\u2010overexpressing pheochromocytoma (PC12) cells with IC<jats:sub>50<\/jats:sub> values similar to the potency of bupropion. Microdialysis showed that \u0394<jats:sup>3<\/jats:sup>,2\u2010hydroxybakuchiol increased dopamine and norepinephrine concentration in rat striatum. In summary, \u0394<jats:sup>3<\/jats:sup>,2\u2010hydroxybakuchiol exerts antidepressant effects on various types of depression models through a possible mechanism of monoamine transporter inhibition.<\/jats:p>","DOI":"10.1155\/2018\/1325141","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T23:30:32Z","timestamp":1529537432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u0394<sup>3<\/sup>,2\u2010Hydroxybakuchiol Attenuates Depression in Multiple Rodent Models Possibly by Inhibition of Monoamine Transporters in Brain"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-3052","authenticated-orcid":false,"given":"Gang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-he","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"DEPRESSION: A Global Crisis.http:\/\/www.who.int\/mental_health\/management\/depression\/wfmh_paper_depression_wmhd_2012.pdf?ua=1."},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.830102"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.04.009"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-411512-5.00009-9"},{"key":"e_1_2_11_5_2","first-page":"715","article-title":"Emotional disease treated with TCM","volume":"32","author":"Zhang L. 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