{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:26:05Z","timestamp":1788953165712,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,10,22]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The TAVR procedure is associated with a substantial risk of thrombosis. Current guidelines recommend catheter-based aortic valve implantation for prohibitive-high-risk patients with severe aortic valve stenosis but acknowledge that the aetiology and mechanism of thrombosis are unclear.<jats:italic>Methods<\/jats:italic>. From 2015 to 2018, 607 patients with severe aortic valve stenosis underwent either self-expandable or balloon-expandable catheter-based aortic valve implantation at our institute. A complementary study was designed to support computed tomography as a predictor of complications using an advanced biomodelling process through finite element analysis (FEA). The primary evaluation of study was the thrombosis of the valve at 12 months.<jats:italic>Results<\/jats:italic>. At 12 months, 546 patients had normal valvular function. 61 patients had THVT while 6 showed thrombosis and dislodgement with deterioration to NYHA Class IV requiring rehospitalization. The FEA biomodelling revealed a strong link between solid uncrushed calcifications, delayed dislodgement of TAVR and late thrombosis. We observed an interesting phenomenon of fibrosis\/calcification originating at the level of the misplaced valve, which was the primary cause of coronary obstruction.<jats:italic>Conclusion<\/jats:italic>. The use of cardiac CT and predictive biomodelling should be integrated into routine practice for the selection of TAVR candidates and as a predictor of negative outcomes given the lack of accurate investigations available. This would assist in effective decision-making and diagnosis especially in a high-risk cohort of patients.<\/jats:p>","DOI":"10.1155\/2018\/1346308","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T23:30:44Z","timestamp":1540251044000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Complementary Role of the Computed Biomodelling through Finite Element Analysis and Computed Tomography for Diagnosis of Transcatheter Heart Valve Thrombosis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-5360","authenticated-orcid":true,"given":"Francesco","family":"Nappi","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mazzocchi","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet Singh","family":"Avtaar Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-9118","authenticated-orcid":true,"given":"Simone","family":"Morganti","sequence":"additional","affiliation":[{"name":"Department of Electrical, Computer, and Biomedical Engineering, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Sablayrolles","sequence":"additional","affiliation":[{"name":"Department of Imaging, Centre Cardiologique du Nord de Saint-Denis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hopital La Pitie Salpetriere, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.09.030"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.105"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.121672"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00986-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.078"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu238"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.112208"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.06.009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01122-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.12.042"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.015"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01119-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00360-5"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03338-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01409-5"},{"key":"16","first-page":"I129","volume":"13 (suppl i)","year":"2001","journal-title":"Seminars in Thoracic and Cardiovascular Surgery"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.05.055"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.03.056"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00291-R"},{"issue":"4","key":"20","first-page":"489","volume":"10","year":"2001","journal-title":"Journal of Heart Valve Disease"},{"issue":"3-4","key":"21","first-page":"199","volume":"11","year":"2001","journal-title":"Journal of Long-Term Effects of Medical Implants"},{"key":"22","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0022-5223(94)70298-5","volume":"108","year":"1994","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02992-7"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.10.070"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.09.028"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.071"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.032"},{"key":"28","first-page":"I294","volume":"116 (11 suppl)","year":"2007","journal-title":"Circulation"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01124-2"},{"key":"30","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","volume":"374","year":"2016","journal-title":"The New England Journal of Medicine"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60290-2"},{"key":"32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2217\/ica.12.73","volume":"5","year":"2013","journal-title":"Journal of Interventional Cardiology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1115\/1.2049337"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.08.010"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-013-0532-x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.05.008"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.06.007"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2015.1058928"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx244"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030729"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.010"},{"key":"42","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","volume":"373","year":"2015","journal-title":"The New England Journal of Medicine"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-7825(96)01147-4"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.11.015"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.08.056"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-9940-6"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.11.002"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw423"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.582882"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.04.049"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.252866"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.03.015"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.11.014"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23275"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.11.034"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.033"},{"key":"59","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jacc.2013.07.040","volume":"62","year":"2013","journal-title":"Journal of the American College of Cardiology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/1346308.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/1346308.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/1346308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:25:13Z","timestamp":1605299113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/1346308\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":57,"alternative-id":["1346308","1346308"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1346308","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]}}}