{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:27Z","timestamp":1787017827611,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,7,9]]},"abstract":"<jats:p>\n                    Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovitis, hyperplasia, and the destruction of bone and cartilage. A variety of immunosuppressive biological agents have been developed because the pathogenesis of RA is related predominantly to the inflammatory response. However, rheumatoid arthritis fibroblast-like synovial cells (RAFLS), which are known to play an important role in RA progression, exhibit resistance to immunosuppressants through cancer-like properties. In this study, we identified a novel therapeutic compound for RA, which reduced inflammation and the abnormal proliferation of RAFLS in natural product library made from Korean native plants.\n                    <jats:italic>Eupatorium japonicum<\/jats:italic>\n                    Thunb. (EJT) extract, a component of the natural product library, most effectively reduced viability through the induction of ROS-mediated apoptosis in a dose-dependent manner. In addition, the increased ROS induced the expression of ATF4 and CHOP, key players in ER stress-mediated apoptosis. Interestingly, EJT extract treatment dose-dependently reduced the expression of IL-1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and the transcription of MMP-9, which were induced by TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    treatment, through the inhibition of NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B and p38 activation. Collectively, we found that EJT extract exerted apoptotic effects through increases in ROS production and CHOP expression and exerted anti-inflammatory effects through the suppression of NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B activation, IL-1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    expression, and MMP-9 transcription.\n                  <\/jats:p>","DOI":"10.1155\/2018\/1383697","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T19:30:54Z","timestamp":1531164654000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["Apoptotic and Anti-Inflammatory Effects of\n                    <i>Eupatorium japonicum<\/i>\n                    Thunb. in Rheumatoid Arthritis Fibroblast-Like Synoviocytes"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-3394","authenticated-orcid":true,"given":"Jong-Il","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Joon","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Gyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of 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