{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:43:20Z","timestamp":1773866600882,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UEM"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background and Objectives<\/jats:italic>. Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of <jats:italic>TNF<\/jats:italic> and <jats:italic>IL17<\/jats:italic> genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in a mixed Brazilian population. <jats:italic>Methods<\/jats:italic>. Genotyping of <jats:italic>TNF<\/jats:italic>-308 (rs1800629), <jats:italic>TNF<\/jats:italic>-238 (rs361525), <jats:italic>IL17A<\/jats:italic> (rs2275913), <jats:italic>IL17F<\/jats:italic> (rs763780), and <jats:italic>HLA-B27<\/jats:italic> polymorphisms was performed in 243 patients with SpA and 210 controls from Southern Brazil using SSOP-Luminex (One Lambda) and PCR-SSP assays. <jats:italic>Results<\/jats:italic>. Significant associations were confirmed between the HLA-B27 marker and SpA, AS, and PsA diseases. While <jats:italic>TNF<\/jats:italic>-308 (rs1800629) AA\/GA, <jats:italic>IL17A<\/jats:italic> (rs2275913) AA\/GA, and <jats:italic>IL17F<\/jats:italic> (rs763780) CC\/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of <jats:italic>HLA-B27<\/jats:italic>, <jats:italic>TNF<\/jats:italic>-238 (rs361525) GA\/AA, <jats:italic>IL17A<\/jats:italic> (rs2275913) AA\/GA, and <jats:italic>IL17F<\/jats:italic> (rs763780) genotypes was associated with PsA. <jats:italic>Conclusion<\/jats:italic>. In this Brazilian population, <jats:italic>TNF<\/jats:italic> and <jats:italic>IL17<\/jats:italic> gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with overall SpA, and, specifically, with AS and PsA, regardless of gender and <jats:italic>HLA-B27<\/jats:italic>. However, future larger studies with different ethnicities may be necessary to confirm these genetic associations.<\/jats:p>","DOI":"10.1155\/2018\/1395823","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T19:30:55Z","timestamp":1524166255000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Influence of <i>TNF<\/i> and <i>IL17<\/i> Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population"],"prefix":"10.1155","volume":"2018","author":[{"given":"Marco A.","family":"Rocha Loures","sequence":"first","affiliation":[{"name":"Department of Medicine, Maringa State University, Maring\u00e1, PR, Brazil"},{"name":"Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-7823","authenticated-orcid":true,"given":"Luciana C.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maring\u00e1, PR, Brazil"},{"name":"Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maring\u00e1, PR, Brazil"},{"name":"Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean L.","family":"Meneguetti","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela F.","family":"Martines","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janisleya S. 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