{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:47:00Z","timestamp":1789519620553,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Acute and chronic bacterial prostatitis in outpatients is commonly treated with oral fluoroquinolones; however, the worldwide dissemination of multidrug-resistant (MDR) <jats:italic>Escherichia coli<\/jats:italic> has resulted in therapeutic failures with fluoroquinolones. We reviewed the literature regarding the use of oral fosfomycin in the treatment of acute and chronic prostatitis caused by MDR <jats:italic>E. coli<\/jats:italic>. All English-language references on PubMed from 1986 to June 2017, inclusive, were reviewed from the search \u201cfosfomycin prostatitis.\u201d Fosfomycin demonstrates potent in vitro activity against a variety of antimicrobial-resistant <jats:italic>E. coli<\/jats:italic> genotypes\/phenotypes including ciprofloxacin-resistant, trimethoprim-sulfamethoxazole-resistant, extended-spectrum <jats:italic>\u03b2<\/jats:italic>-lactamase- (ESBL-) producing, and MDR isolates. Fosfomycin attains therapeutic concentrations (\u22654\u2009<jats:italic>\u03bc<\/jats:italic>g\/g) in uninflamed prostatic tissue and maintains a high prostate\/plasma ratio up to 17 hours after oral administration. Oral fosfomycin\u2019s clinical cure rates in the treatment of bacterial prostatitis caused by antimicrobial-resistant <jats:italic>E. coli<\/jats:italic> ranged from 50 to 77% with microbiological eradication rates of &gt;50%. An oral regimen of fosfomycin tromethamine of 3\u2009g\u00b7q 24\u2009h for one week followed by 3\u2009g\u00b7q 48\u2009h for a total treatment duration of 6\u201312 weeks appeared to be effective. Oral fosfomycin may represent an efficacious and safe treatment for acute and chronic prostatitis caused by MDR <jats:italic>E. coli<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2018\/1404813","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:30:35Z","timestamp":1517337035000},"page":"1-9","source":"Crossref","is-referenced-by-count":25,"title":["Oral Fosfomycin for the Treatment of Acute and Chronic Bacterial Prostatitis Caused by Multidrug-Resistant <i>Escherichia coli<\/i>"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3238-0082","authenticated-orcid":true,"given":"George G.","family":"Zhanel","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-464X","authenticated-orcid":true,"given":"James A.","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1086\/652861"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.15570\/actaapa.2015.8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt027"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00066-11"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02399-13"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02611-15"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2082693"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit704"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.07.007"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ443"},{"issue":"2","key":"12","first-page":"144","volume":"93","year":"2016","journal-title":"American Family Physician"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/qco.0000000000000222"},{"issue":"4","key":"14","first-page":"397","volume":"82","year":"2015","journal-title":"American Family Physician"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.025"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009071.pub2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00125-13"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00912-17"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00673-15"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.01.020"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.uti-0004-2012"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.12.019"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv067"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ436"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/1404813.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/1404813.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2018\/1404813.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:30:36Z","timestamp":1517337036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjidmm\/2018\/1404813\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":23,"alternative-id":["1404813","1404813"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1404813","relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}