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The exploration of effective interference is important. Anti\u2010<jats:italic>\u03b2<\/jats:italic>1\u2010adrenergic receptor autoantibody (<jats:italic>\u03b2<\/jats:italic>1\u2010AAB) is highly correlated with myocardial dysfunction. The actions and underlying mechanisms of honokiol (HNK) in <jats:italic>\u03b2<\/jats:italic>1\u2010AAB\u2010positive patients await to be unraveled. In this study, we established a rat model of <jats:italic>\u03b2<\/jats:italic>1\u2010AAB positive with myocardial dysfunction. Cardiac function following <jats:italic>\u03b2<\/jats:italic>1\u2010AR\u2010ECII administration was analyzed using the VisualSonics Vevo 770 High\u2010Resolution In Vivo Imaging System. The levels of autophagy\u2010related proteins were detected by Western blotting. Our data revealed that HNK reversed <jats:italic>\u03b2<\/jats:italic>1\u2010AAB\u2010induced effects and protected myocardial tissues from dysfunction. After HNK treatment, the cardiac contractile ability increased and the LDH activity decreased. HNK attenuated myocardial degeneration. In addition, HNK promoted the activation of the AMP\u2010dependent protein kinase\/Unc\u201051\u2010like autophagy activating kinase (AMPK\/ULK) pathway and activated autophagy. These results suggest that HNK protects against <jats:italic>\u03b2<\/jats:italic>1\u2010AAB\u2010induced myocardial dysfunction via activation of autophagy and it may be a potentially therapeutic compound for <jats:italic>\u03b2<\/jats:italic>1\u2010AAB\u2010positive myocardial diseases.<\/jats:p>","DOI":"10.1155\/2018\/1640804","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T23:36:04Z","timestamp":1531956964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Honokiol Protects against Anti\u2010<i>\u03b2<\/i>1\u2010Adrenergic Receptor Autoantibody\u2010Induced Myocardial Dysfunction via Activation of 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