{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:20:27Z","timestamp":1751516427343,"version":"3.41.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development. The aim of the present study was to determine the influence of single nucleotide polymorphism (SNP) of<jats:italic>CYP4F2<\/jats:italic>(rs1558139) and serum levels of IL-17A on ON development.<jats:italic>Materials and Methods<\/jats:italic>. Forty patients with ON and 164 control subjects were evaluated. Patients were divided by gender, also ON patients were divided into two subgroups: ON with and without multiple sclerosis (MS).<jats:italic>CYP4F2<\/jats:italic>rs1558139 was genotyped using real-time PCR. Serum IL-17A levels were measured using ELISA IL-17A kits.<jats:italic>Results<\/jats:italic>. We found that A\/A genotype of<jats:italic>CYP4F2<\/jats:italic>rs1558139 was statistically significantly more frequent in men with ON and MS than in women: 57.1% versus 0%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>. Also, allele A was statistically significantly more frequent in men with ON and MS than in women: 71.4% versus 37.5%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>. Serum levels of IL-17A were higher in ON group than in control group: (median, IQR): 20.55\u2009pg\/ml, 30.66\u2009pg\/ml versus 8.97\u2009pg\/ml, 6.24\u2009pg\/ml,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>.<jats:italic>Conclusion<\/jats:italic>. The higher IL-17A levels were found to be associated with ON, while allele A at rs1558139 was associated only with ON with MS in male patients.<\/jats:p>","DOI":"10.1155\/2018\/1686297","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T23:30:54Z","timestamp":1521156654000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Association of Optic Neuritis with<i>CYP4F2<\/i>Gene Single Nucleotide Polymorphism and IL-17A Concentration"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-9598","authenticated-orcid":true,"given":"Mantas","family":"Banevicius","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 Kaunas, 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