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However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system. Two types of voltage-gated sodium channels, Na<jats:sub>v<\/jats:sub>1.7 and Na<jats:sub>v<\/jats:sub>1.8, as well as<jats:italic>\u03b1<\/jats:italic>2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG). Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>) via<jats:italic>\u03b1<\/jats:italic>2-adrenoceptors in dissociated, small-sized TG neurons. Dexmedetomidine caused a concentration-dependent inhibition of<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>in small-sized TG neurons.<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>inhibition by dexmedetomidine was blocked by yohimbine, a competitive<jats:italic>\u03b1<\/jats:italic>2-adrenoceptor antagonist. Dexmedetomidine-induced inhibition of<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>was mediated by G protein-coupled receptors (GPCRs) as this effect was blocked by intracellular perfusion with the G protein inhibitor GDP<jats:italic>\u03b2<\/jats:italic>-S. Our results suggest that the<jats:italic>I<\/jats:italic><jats:sub>Na<\/jats:sub>inhibition in small-sized TG neurons, mediated by the activation of Gi\/o protein-coupled<jats:italic>\u03b1<\/jats:italic>2-adrenoceptors, might contribute to the analgesic effects of dexmedetomidine in the trigeminal system. Therefore, these new findings highlight a potential novel target for analgesic drugs in the orofacial region.<\/jats:p>","DOI":"10.1155\/2018\/1782719","type":"journal-article","created":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T23:31:23Z","timestamp":1535931083000},"page":"1-7","source":"Crossref","is-referenced-by-count":18,"title":["Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via<i>\u03b1<\/i>2-Adrenoceptors in Trigeminal Ganglion Neurons"],"prefix":"10.1155","volume":"2018","author":[{"given":"Sang-Taek","family":"Im","sequence":"first","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Yi","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Gachon University, Gil Medical Center, Incheon 21565, Republic of 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