{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:45:33Z","timestamp":1740159933737,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005601","name":"University of Ghana","doi-asserted-by":"publisher","award":["URF\/9\/ILG-076\/2015-2016"],"award-info":[{"award-number":["URF\/9\/ILG-076\/2015-2016"]}],"id":[{"id":"10.13039\/501100005601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis Research and Treatment"],"published-print":{"date-parts":[[2018,9,24]]},"abstract":"<jats:p>The burden of both tuberculosis (TB) and diabetes mellitus in developing countries including Ghana is high; often, the two coexist and impact each other negatively.<jats:italic>Objective<\/jats:italic>. The study aimed to determine the prevalence and predictive factors of dysglycaemia among newly diagnosed smear positive tuberculosis patients at a tertiary tuberculosis treatment centre in Ghana.<jats:italic>Methods<\/jats:italic>. Dysglycaemia at diagnosis was determined by the use of oral glucose tolerance test (OGTT), while sputum smear microscopy was used to assess the sputum status. Only smear positive patients were included in the study. Information on sociodemographic, anthropometrical, clinical, and medication history was also obtained.<jats:italic>Results<\/jats:italic>. In all, 146 participants, aged 18 to 75 years with a mean age of 38.7 years comprising 115 (78.8%) males and 31 (21.2%) females, were involved in the analysis. Upon initial screening, using fasting plasma glucose (FPG), 91.1 % had normal fasting level, 5.5 % had impaired fasting, and 3.4% were diagnosed with diabetes. Using 2-hour postprandial values (2HPP), 59.6% had normal plasma glucose, 28.8 % had impaired glucose tolerance (IGT), and 11.6 % were diagnosed with diabetes. Overall, the prevalence of dysglycaemia (i.e., impaired fasting and diabetes) was 8.9% (95% CI: 5.21\u201314.82%) with FPG test and 40.4% (95% CI: 32.68\u201348.65%) with 2HPP test. The analysis revealed that 2HPP was associated with high mean age compared to FPG (36.67 \u00b1 13.97 versus 41.69 \u00b1 13.97, p-value = 0.033). In addition, marital status was significantly associated with FPG status of patients<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi mathvariant=\"normal\">p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn mathvariant=\"normal\">0.028<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>.<jats:italic>Conclusion<\/jats:italic>. The prevalence of dysglycaemia was high among smear positive TB patients in Ghana. Higher mean age and marital status were associated with abnormal glucose tolerance and fasting plasma glucose, respectively. Clinical management of patients with tuberculosis should include screening for diabetes.<\/jats:p>","DOI":"10.1155\/2018\/1830372","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T23:30:39Z","timestamp":1537831839000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Examination of Dysglycaemia among Newly Diagnosed Tuberculosis Patients in Ghana: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-7492","authenticated-orcid":true,"given":"Ernest","family":"Yorke","sequence":"first","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Boima","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida Dzifa","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-2461","authenticated-orcid":true,"given":"Yacoba","family":"Atiase","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-3703","authenticated-orcid":true,"given":"Josephine","family":"Akpalu","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-5686","authenticated-orcid":true,"given":"Alfred Edwin","family":"Yawson","sequence":"additional","affiliation":[{"name":"Department of Community Health, School of Public Health, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Ganu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korle-Bu Teaching Hospital, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Forson","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Charles","family":"Mate-Kole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine & Dentistry, College of Health Sciences, Korle-Bu, Ghana"},{"name":"Centre for Ageing Studies, College of Humanities, University of Ghana, Ghana"},{"name":"Department of Psychology, College of Humanities, University of Ghana, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"first-page":"813","volume-title":"Infection and diabetes mellitus","year":"1991","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-11-28"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/1742395307081502"},{"issue":"7","key":"5","volume":"5","year":"2008","journal-title":"PLoS Medicine"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1086\/519841"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-81"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-12-58"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2010.02632.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(90)90040-F"},{"issue":"6","key":"11","first-page":"1016","volume":"76","year":"1957","journal-title":"Am Rev Tuberc"},{"issue":"3","key":"12","first-page":"2","volume":"47","year":"2000","journal-title":"Ind J Tub"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/clinchem\/48.3.436","volume":"48","year":"2002","journal-title":"Clin Chem"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102008000600003"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1584"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.4.574"},{"issue":"1","key":"19","first-page":"74","volume":"10","year":"2006","journal-title":"The International Journal of Tuberculosis and Lung Disease"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1801"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.51.5s.1.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.11.018"},{"issue":"1","key":"25","volume":"2","year":"2013","journal-title":"Infectious Diseases of Poverty"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/828939"},{"issue":"11","key":"30","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00185-8"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.758"}],"container-title":["Tuberculosis Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2018\/1830372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2018\/1830372.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2018\/1830372.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T23:21:56Z","timestamp":1605050516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/trt\/2018\/1830372\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":25,"alternative-id":["1830372","1830372"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1830372","relation":{},"ISSN":["2090-150X","2090-1518"],"issn-type":[{"type":"print","value":"2090-150X"},{"type":"electronic","value":"2090-1518"}],"subject":[],"published":{"date-parts":[[2018,9,24]]}}}