{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:06:48Z","timestamp":1776737208392,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Program of Changzhou Health and Family Planning Commission","award":["ZD201511"],"award-info":[{"award-number":["ZD201511"]}]},{"name":"Major Science and Technology Program of Changzhou Health and Family Planning Commission","award":["CE20175039"],"award-info":[{"award-number":["CE20175039"]}]},{"name":"Science and Technology Support Program of Changzhou","award":["ZD201511"],"award-info":[{"award-number":["ZD201511"]}]},{"name":"Science and Technology Support Program of Changzhou","award":["CE20175039"],"award-info":[{"award-number":["CE20175039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. <jats:italic>Methods<\/jats:italic>. This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50\u2009<jats:italic>\u03bc<\/jats:italic>g\/0.1\u2009ml). This paper reviews and analyzes the patients\u2019 basic state, surgical intervention, medicinal treatment, and outcomes. <jats:italic>Results<\/jats:italic>. The mean sizes of infiltration and ulcer were (5.54\u2009\u00b1\u20091.32)mm and (3.46\u2009\u00b1\u20091.03)mm, respectively, and the mean depth was (315.43\u2009\u00b1\u200957.72)<jats:italic>\u03bc<\/jats:italic>m. Twelve of the patients had satellite lesion, and 2 suffered hypopyon. After intrastromal voriconazole, the size of infiltration decreased significantly to (4.32\u2009\u00b1\u20091.10)mm (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), but there was no significant change in ulcer size ((3.36\u2009\u00b1\u20090.92)mm, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.082<\/mml:mn><\/mml:math>). Thirteen patients were cured after corneal debridement. The mean healing time was (15.38\u2009\u00b1\u20097.38) days. Excluding one cured patient with optic nerve atrophy and one patient for whom the treatment failed, the mean best-corrected visual acuity after healing was (0.23\u2009\u00b1\u20090.18)LogMAR, a significant improvement compared to pretreatment (0.87\u2009\u00b1\u20090.57(LogMAR), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The mean corneal astigmatism was (1.3\u2009\u00b1\u20091.6)D of 12 cured patients after healing and (1.0\u2009\u00b1\u20090.7)D at final follow-up, and there was no significant difference (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.374<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Corneal debridement combined with intrastromal voriconazole is a secure and effective treatment for recalcitrant fungal keratitis.<\/jats:p>","DOI":"10.1155\/2018\/1875627","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T18:33:30Z","timestamp":1519065210000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-6263","authenticated-orcid":true,"given":"Yajie","family":"Sun","sequence":"first","affiliation":[{"name":"The Third People\u2019s Hospital of Changzhou, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Sun","sequence":"additional","affiliation":[{"name":"The Third People\u2019s Hospital of Changzhou, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukai","family":"Chen","sequence":"additional","affiliation":[{"name":"The Third People\u2019s Hospital of Changzhou, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-0744","authenticated-orcid":true,"given":"Guohua","family":"Deng","sequence":"additional","affiliation":[{"name":"The Third People\u2019s Hospital of Changzhou, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-012-9643-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12126"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305412"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004241.pub4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.192815"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.023"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2013.03.004"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-111814"},{"key":"9","year":"2002"},{"issue":"2","key":"10","first-page":"148","volume":"42","year":"2009","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182100993"},{"issue":"10","key":"12","first-page":"373","volume":"23","year":"1991","journal-title":"Annals of Ophthalmology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e318036bd47"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200408000-00008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.136515"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0687-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.01.008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3623-3626.2003"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.02.023"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S63516"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31818225f8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301129"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00569-11"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.04.019"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2018\/1875627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2018\/1875627.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2018\/1875627.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T18:33:34Z","timestamp":1519065214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2018\/1875627\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"alternative-id":["1875627","1875627"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1875627","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}