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AIRmax and AIRmin mouse lines differ in their susceptibility to PIA, and linkage analysis in this model mapped arthritis severity QTLs in chromosomes 5 and 8. miRNAs are a class of small RNA molecules that have been extensively studied in the development of arthritis. We analyzed miRNA and gene expression profiles in peritoneal cells of AIRmax and AIRmin lines, in order to evaluate the genetic architecture in this model. Susceptible AIRmax mice showed higher gene (2025 vs 1043) and miRNA (240 vs 59) modulation than resistant AIRmin mice at the onset of disease symptoms. miR-132-3p\/212-3p, miR-106-5p, miR-27b-3p, and miR-25-3p were among the miRNAs with the highest expression in susceptible animals, showing a negative correlation with the expression of predicted target genes (<jats:italic>Il10<\/jats:italic>, <jats:italic>Cd69<\/jats:italic>, and <jats:italic>Sp1r1<\/jats:italic>). Our study showed that global gene and miRNA expression profiles in peritoneal cells of susceptible AIRmax and resistant AIRmin lines during pristane-induced arthritis are distinct, evidencing interesting targets for further validation.<\/jats:p>","DOI":"10.1155\/2018\/1928405","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T18:30:35Z","timestamp":1544985035000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Jussara Gon\u00e7alves","family":"Fernandes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica, Instituto Butantan, S\u00e3o Paulo 05503000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Borrego","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica, 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