{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:16:52Z","timestamp":1762431412858,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Toxoplasma gondii<\/jats:italic> infects up to one-third of the world\u2019s population, making it the protozoan that most infects people worldwide. Among the forms of presentation of toxoplasmosis, hepatitis is probably the least frequent with only a few case reports in the world\u2019s medical literature. Despite the fact that the first diagnostic test is the serology using the ELISA technique because its sensitivity is close to 100% in our case, it was reported negative. The biopsy gave the definitive diagnosis, and we were able to start treatment immediately. Although the first line of treatment is sulfadiazine and pyrimethamine, our sulfate allergic patient received an alternative regimen of doxycycline, clindamycin, and azithromycin with a good response. This is the only case of <jats:italic>Toxoplasma<\/jats:italic> hepatitis reported in Mexico and the only one in the world with negative serology with a good response to second-line treatment.<\/jats:p>","DOI":"10.1155\/2018\/1951936","type":"journal-article","created":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:31:34Z","timestamp":1522611094000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Acute Seronegative <i>Toxoplasma gondii<\/i> Hepatitis Allergic to First-Line Treatment"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0080-487X","authenticated-orcid":true,"given":"Fernando","family":"De la Garza-Salazar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Christus Muguerza Hospital Alta Especialidad, Universidad de Monterrey, San Pedro Garza Garc\u00eda, NL 64060, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alejandro","family":"Cort\u00e9z-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza, NL 64460, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Decanini-Arcaute","sequence":"additional","affiliation":[{"name":"Department of Pathology, Christus Muguerza Hospital Alta Especialidad, Universidad de Monterrey, San Pedro Garza Garc\u00eda, NL 64060, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-0094","authenticated-orcid":true,"given":"Adri\u00e1n","family":"Camacho-Ortiz","sequence":"additional","affiliation":[{"name":"Epidemiologic Hospital Coordination, Hospital Universitario Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza, NL 64460, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(00)00124-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-271"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2012.08.004"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-311x200200060002400028"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(67)90235-8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198001173020316"},{"issue":"15","key":"7","first-page":"595","volume":"99","year":"1992","journal-title":"Medicina Cl\u00ednica"},{"issue":"4","key":"8","first-page":"323","volume":"31","year":"1996","journal-title":"Proceedings of the Annales de Medecine Interne"},{"issue":"4","key":"9","first-page":"260","volume":"31","year":"2007","journal-title":"T\u00fcrkiye Parazitoloji Dergisi"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.jjid.2014.422"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197803092981006"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197905103001907"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.58.679.299"},{"year":"2010","key":"14","first-page":"210"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.05.1014"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.09.009"},{"year":"2001","key":"17"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s60973"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/1951936.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/1951936.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/1951936.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:31:34Z","timestamp":1522611094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2018\/1951936\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":18,"alternative-id":["1951936","1951936"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1951936","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2018]]}}}