{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:37:18Z","timestamp":1787830638491,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770568"],"award-info":[{"award-number":["81770568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012017yjsy198"],"award-info":[{"award-number":["2012017yjsy198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["81770568"],"award-info":[{"award-number":["81770568"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2012017yjsy198"],"award-info":[{"award-number":["2012017yjsy198"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To explore the efficacy and safety of immunosuppressive therapy for the treatment of primary biliary cirrhosis-autoimmune hepatitis (PBC-AIH) overlap syndrome accompanied by decompensated cirrhosis.<jats:italic> Methods<\/jats:italic>. A cohort study was performed to evaluate the usefulness of immunosuppressive therapy in this unique group. This cohort study was performed between October 2013 and June 2017 and included 28 biopsy-proven patients diagnosed according to the Paris criteria. The therapies included ursodeoxycholic acid (UDCA) alone (N=14) or in combination with immunosuppression (IS) therapy (N=14). The primary endpoints were biochemical remission, liver-related adverse events, transplant-free survival, and drug side-effects.<jats:italic> Results<\/jats:italic>. The frequency of biochemical remission for the AIH features was significantly higher in the UDCA+IS group than in the UDCA-only group (60.0 versus 9.1%, P=0.024) after 12 months of therapy but not after 3 and 6 months (28.6 versus 0%, P=0.165; 35.7 versus 7.1%, P=0.098). The rates of liver-related adverse events were lower in the combined group (2\/14 versus 9\/14, P=0.018). The Kaplan-Meier estimate showed that the transplant-free survival was distinct between the two groups (P=0.019). In the UDCA+IS group, mild and transient leukopenia occurred in two patients receiving azathioprine (AZA), and an infection was observed in one patient receiving mycophenolate mofetil (MMF).<jats:italic> Conclusions<\/jats:italic>. PBC-AIH patients with decompensated cirrhosis receiving a combination of UDCA and immunosuppressors presented with higher biochemical remission rates and experienced fewer liver-related adverse events, implying that the combined treatment might be a better therapeutic option for strictly defined decompensated PBC-AIH overlap syndrome.<\/jats:p>","DOI":"10.1155\/2018\/1965492","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T23:31:36Z","timestamp":1533252696000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and Safety of Immunosuppressive Therapy for PBC\u2013AIH Overlap Syndrome Accompanied by Decompensated Cirrhosis: A Real-World Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xiaoli","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoting","family":"Men","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changli","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-9342","authenticated-orcid":true,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280210"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3368"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280203"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(07)89323-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.016"},{"issue":"3","key":"6","first-page":"148","volume":"10","year":"2015","journal-title":"Przegl\u0105d Gastroenterologiczny"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02830.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12721"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.012"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05223.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24080"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"issue":"3","key":"17","first-page":"290","volume":"67","year":"2004","journal-title":"Acta Gastro-Enterologica Belgica"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/his.12384"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000765"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.021"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.017"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30902"},{"issue":"47","key":"24","first-page":"1195","volume":"49","year":"2002","journal-title":"Hepato-Gastroenterology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8583-2"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.011"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/1965492.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/1965492.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/1965492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T22:56:00Z","timestamp":1589928960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2018\/1965492\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,2]]},"references-count":26,"alternative-id":["1965492","1965492"],"URL":"https:\/\/doi.org\/10.1155\/2018\/1965492","relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,2]]}}}