{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:25:00Z","timestamp":1778300700075,"version":"3.51.4"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001343","name":"University of Pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>\u2217<\/mml:mo><\/mml:math>02:02g (0.096), B<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo>\u2217<\/mml:mo><\/mml:math>07:02g (0.082), C<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo>\u2217<\/mml:mo><\/mml:math>07:02g (0.180), DQB1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo>\u2217<\/mml:mo><\/mml:math>06:02 (0.157), and DRB1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mo>\u2217<\/mml:mo><\/mml:math>15:01 (0.072). The most common haplotype was A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mo>\u2217<\/mml:mo><\/mml:math>03:01g~B<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mo>\u2217<\/mml:mo><\/mml:math>07:02g~C<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mo>\u2217<\/mml:mo><\/mml:math>07:02g~DQB1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mo>\u2217<\/mml:mo><\/mml:math>06:02~DRB1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mo>\u2217<\/mml:mo><\/mml:math>15:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.<\/jats:p>","DOI":"10.1155\/2018\/2031571","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T19:31:00Z","timestamp":1524511860000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-8973","authenticated-orcid":true,"given":"Mqondisi","family":"Tshabalala","sequence":"first","affiliation":[{"name":"Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Institute for Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ingram","sequence":"additional","affiliation":[{"name":"South African Bone Marrow Registry (SABMR), P.O. Box 13353 Mowbray, Cape Town 7705, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Schlaphoff","sequence":"additional","affiliation":[{"name":"South African Bone Marrow Registry (SABMR), P.O. Box 13353 Mowbray, Cape Town 7705, South Africa"},{"name":"Laboratory for Tissue Immunology, National Health Laboratory Service, Groote Schuur Hospital, C21 Anzio Street, Observatory, Cape Town 7925, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Borrill","sequence":"additional","affiliation":[{"name":"South African Bone Marrow Registry (SABMR), P.O. 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