{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:38:25Z","timestamp":1789763905683,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["221057"],"award-info":[{"award-number":["221057"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage. Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron. This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE) in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events. Adult Wistar male rats were divided into euthyroid and hypothyroid groups. Thyroidectomy with parathyroid gland reimplementation caused hypothyroidism at three weeks postsurgery. Oxidative stress, redox environment, and antioxidant enzyme markers, as well as the expression of the ERE through the pathways of PERK, ATF6, and IRE1, were evaluated at the 3rd and 4th weeks postsurgery. We found a rise in ROS and nitrite production; also, catalase increased and glutathione peroxidase diminished their activities. These events promote an enhancement of the lipoperoxidation, as well as of <jats:italic>\u03b3<\/jats:italic>\u2010GT, myeloperoxidase, and caspase 3 activities. With respect to ERE, there were ATF6, IRE1, and GADD153 overexpressions with a reduction in mitochondrial activity and GSH<jats:sup>2<\/jats:sup>\/GSSG ratio. We conclude that the endoplasmic reticulum stress might play a pivotal role in the activation of hypothyroidism\u2010induced hippocampal cell death.<\/jats:p>","DOI":"10.1155\/2018\/2089404","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T23:31:40Z","timestamp":1521588700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-4129","authenticated-orcid":false,"given":"Alejandra Paola","family":"Torres-Manzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-1945","authenticated-orcid":false,"given":"Margarita","family":"Franco-Col\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-9829","authenticated-orcid":false,"given":"Vanessa","family":"Blas-Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Pineda-Reynoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-5590","authenticated-orcid":false,"given":"Edgar","family":"Cano-Europa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0205"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20476"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(97)00089-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903220405"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.02.017"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-008-9099-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087648"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074134"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400779"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01805-1"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.5.3.253"},{"key":"e_1_2_8_12_2","first-page":"1712","article-title":"Regional cerebral blood flow in patients with mild hypothyroidism","volume":"45","author":"Krausz Y.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01110-9"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0797"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0478"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00306-D"},{"key":"e_1_2_8_17_2","first-page":"137","article-title":"Hypothyroidism during neonatal and perinatal period induced by thyroidectomy of the mother causes depressive-like behavior in prepubertal rats","volume":"6","author":"Pineda-Reynoso M.","year":"2010","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_8_18_2","first-page":"637","article-title":"Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity","volume":"13","author":"Ali S. 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