{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:59:26Z","timestamp":1791053966402,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. This study investigated if resveratrol ameliorates diabetic cardiomyopathy by targeting associated oxidative stress mechanisms.<jats:italic> Method<\/jats:italic>. Type 1 diabetes mellitus (DM) in FVB mice was induced by several intraperitoneal injections of a low dose of streptozotocin. Hyperglycemic and age-matched control mice were given resveratrol (10\u2009mg\/kg per day) for 1 month and subsequently monitored for an additional 6 months. Mice were assigned to four groups: control, resveratrol, DM, and DM\/resveratrol. Cardiac function and blood pressure were assessed at 1, 3, and 6 months after DM induction. Oxidative damage and cardiac fibrosis were analyzed by histopathology, real-time PCR, and Western blot.<jats:italic> Result<\/jats:italic>. Mice in the DM group exhibited increased blood glucose levels, cardiac dysfunction, and high blood pressure at 1, 3, and 6 months after DM induction. Resveratrol did not significantly affect blood glucose levels and blood pressure; however, resveratrol attenuated cardiac dysfunction and hypertrophy in DM mice. Resveratrol also reduced DM-induced fibrosis. In addition, DM mice hearts exhibited increased oxidative damage, as evidenced by elevated accumulation of 3-nitrotyrosine and 4-hydroxynonenal, which were both attenuated by resveratrol. Mechanistically, resveratrol increased NFE2-related factor 2 (Nrf2) expression and transcriptional activity, as well as Nrf2\u2019s downstream antioxidative targets.<jats:italic> Conclusion<\/jats:italic>. We demonstrated that resveratrol prevents DM-induced cardiomyopathy, in part, by increasing Nrf2 expression and transcriptional activity.<\/jats:p>","DOI":"10.1155\/2018\/2150218","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T19:30:41Z","timestamp":1520883041000},"page":"1-13","source":"Crossref","is-referenced-by-count":39,"title":["Resveratrol Prevents Diabetic Cardiomyopathy by Increasing Nrf2 Expression and Transcriptional Activity"],"prefix":"10.1155","volume":"2018","author":[{"given":"Guan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Jilin University, Jilin University, Changchun 100032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Jilin University, Jilin University, Changchun 100032, 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