{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:55:13Z","timestamp":1792684513465,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":275,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Poznan University of Physical Education"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Patients with ankylosing spondylitis (AS) have increased production of proinflammatory cytokines, increased oxidants, and decreased antioxidant capacity. The aim of this study was to determine the effect of whole\u2010body cryotherapy (WBC) at \u2212110\u00b0C and \u221260\u00b0C, on disease activity, selected proinflammatory cytokines, and oxidative stress in patients with AS. <jats:italic>Methods<\/jats:italic>. Sixty\u2010five patients with AS were recruited to one of three study procedures: WBC at \u2212110\u00b0C, \u221260\u00b0C, or exercise therapy (non\u2010WBC). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS\u2010CRP), concentration of C\u2010reactive protein (CRP), and the concentrations of interleukin 8 and 17 (IL\u20108, IL\u201017) were measured at the beginning of the study and at the end of the intervention. The concentration of thiobarbituric acid reactive substances (TBARS), as a lipid peroxidation result, and total antioxidant status, an antioxidant organism potential, were measured. <jats:italic>Results<\/jats:italic>. All the studied groups showed significantly decreased posttherapy disease activity expressed as a function of the BASDAI, ASDAS\u2010CRP, and the IL\u20108 concentration. We found that the TBARS concentration after therapy was significantly increased in the WBC at \u2212110\u00b0C group. A comparison of the therapeutic effects between the treatment groups showed a significantly lower BASDAI after therapy in the WBC at \u2212110\u00b0C group compared to the non\u2010WBC group. <jats:italic>Conclusion<\/jats:italic>. WBC at \u2212110\u00b0C had a positive effect on lowering AS clinical activity as measured by the BASDAI.<\/jats:p>","DOI":"10.1155\/2018\/2157496","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T23:33:46Z","timestamp":1538609626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Effect of Whole\u2010Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-623X","authenticated-orcid":false,"given":"Anna","family":"Straburzy\u0144ska-Lupa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-0331","authenticated-orcid":false,"given":"Magdalena 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