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The GM is first loaded into HMS. Then, the outer surface of the GM\/HMS is coated with uniformed ZIF nanoparticles (denoted as GM\/HMS@ZIF). The GM\/HMS@ZIF has been successfully prepared and acts as a capsule for GM. The GM\/HMS@ZIF shows a good biocompatibility and a good cellular uptake in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. The GM is released slowly within 10\u2009h under acidic conditions, which is used to simulate the pH of the endosome and lysosome compartments. The <jats:italic>in vivo<\/jats:italic> assay shows that the signal from fluorescein isothiocyanate (FITC) can be observed after 15 days, when the mice were injected with FITC\/HMS@ZIF. 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