{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:35:33Z","timestamp":1743266133136,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>A simple extractive spectrophotometric technique has been developed and validated for the determination of miconazole nitrate in pure and pharmaceutical formulations. The method is based on the formation of a chloroform-soluble ion-pair complex between the drug and bromocresol green (BCG) dye in an acidic medium. The complex showed absorption maxima at 422\u2009nm, and the system obeys Beer\u2019s law in the concentration range of 1\u201330\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL with molar absorptivity of 2.285\u2009\u00d7\u200910<jats:sup>4<\/jats:sup>\u2009L\/mol\/cm. The composition of the complex was studied by Job\u2019s method of continuous variation, and the results revealed that the mole ratio of drug\u2009:\u2009BCG is 1\u2009:\u20091. Full factorial design was used to optimize the effect of variable factors, and the method was validated based on the ICH guidelines. The method was applied for the determination of miconazole nitrate in real samples.<\/jats:p>","DOI":"10.1155\/2018\/2191072","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T23:30:57Z","timestamp":1524007857000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Development and Validation of an Extractive Spectrophotometric Method for Miconazole Nitrate Assay in Pharmaceutical Formulations"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-1493","authenticated-orcid":true,"given":"Tadele","family":"Eticha","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getu","family":"Kahsay","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, 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