{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:40:28Z","timestamp":1790059228861,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["2\/0074\/14"],"award-info":[{"award-number":["2\/0074\/14"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","award":["2\/0103\/18"],"award-info":[{"award-number":["2\/0103\/18"]}],"id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-15-056"],"award-info":[{"award-number":["APVV-15-056"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Although the role of nitric oxide (NO) in essential hypertension is still unclear, the effects of long\u2010term NO deficiency have not yet been investigated during the critical juvenile period in spontaneously hypertensive rats (SHR). We aimed to analyze the effects of chronic NO synthase (NOS) inhibition on systolic blood pressure (sBP), vasoactivity, morphological changes and superoxide level in the thoracic aorta (TA), NOS activity in different tissues, and general biomarkers of oxidative stress in plasma of young SHR. Four\u2010week\u2010old SHR were treated with N<jats:sup>G<\/jats:sup>\u2010nitro\u2010L\u2010arginine methyl ester (L\u2010NAME, 50\u2009mg\/kg\/day, p.o.) for 4\u20105 weeks. L\u2010NAME treatment induced a transient sBP increase only, and surprisingly, slightly inhibited endothelium\u2010dependent relaxation of TA. Hereby, the inhibition of NOS activity varied from tissue to tissue, ranging from the lowest in the TA and the kidney to the highest in the brain stem. In spite of an increased sensitivity of adrenergic receptors, the maximal adrenergic contraction of TA was unchanged, which was associated with changes in elastin arrangement and an increase in wall thickness. The production of reactive oxygen species in the TA was increased; however, the level of selected biomarkers of oxidative stress did not change. Our findings proved that the TA of young SHR responded to chronic NO deficiency by the development of adaptive mechanisms on the functional (preserved NO\u2010derived vasorelaxation, unincreased contraction) and molecular (preserved NOS activity) level.<\/jats:p>","DOI":"10.1155\/2018\/2502843","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T23:33:53Z","timestamp":1530228833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Chronic NO Synthase Inhibition on the Vasoactive and Structural Properties of Thoracic Aorta, NO Synthase Activity, and Oxidative Stress Biomarkers in Young SHR"],"prefix":"10.1155","volume":"2018","author":[{"given":"Andrea","family":"Berenyiova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ima","family":"Dovinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Kvandova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frantisek","family":"Kristek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3151-5897","authenticated-orcid":false,"given":"Eugene","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-4279","authenticated-orcid":false,"given":"Miroslava","family":"Majzunova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-7468","authenticated-orcid":false,"given":"Sona","family":"Cacanyiova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.21.3.359"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/598271"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.026"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00289.2007"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00424-3"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931581"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2299(200007\/08)50:3\/4<528::AID-DDR36>3.0.CO;2-3"},{"key":"e_1_2_8_8_2","first-page":"501","article-title":"The adaptive role of nitric oxide and hydrogen sulphide in vasoactive responses of thoracic aorta is triggered already in young spontaneously hypertensive rats","volume":"67","author":"Cacanyiova S.","year":"2016","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.83.12.1271"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.198721"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/541871"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113035"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.030"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.001"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2011_04_364"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018070-00010"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930000.55.S1.65"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.2.249"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00632.2005"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-014-0343-2"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000360400"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.146043"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.180"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.185496"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050288"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9460653"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00327.2005"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000133734.32125.c7"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00795-0"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200211000-00017"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.2005.00343.x"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00724.2001"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70846-0"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.09.008"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150711773"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.09.005"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930365"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2009_01_86"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8156594"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4953"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.009"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00270.2011"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.240127"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-20-69"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05317.x"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu111"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/2502843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/2502843.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/2502843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:01:35Z","timestamp":1723028495000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/2502843"}},"subtitle":[],"editor":[{"given":"Jacek","family":"Zielonka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/2502843"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2502843","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2502843"}}