{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:57:49Z","timestamp":1769147869002,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7162123"],"award-info":[{"award-number":["7162123"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Diabetic nephropathy (DN) is a microvascular complication induced by diabetes mellitus (DM), which can affect life quality and long\u2010term prognosis of patients with DM. Angiotensin\u2010converting\u2010enzyme inhibitors (ACEI)\/angiotensin receptor blockers (ARB) are currently recommended for treating DN proteinuria, but patients receiving ACEI\/ARB are at risk of elevated serum creatinine or potassium levels. Based on the \u201cyin\u2010yang\u201d theory of traditional Chinese medicine, the present study explored the effect of QiDiTangShen (QDTS) granules on DN and the phosphorylation balance of tyrosine and serine residues of IRS\u20101. <jats:italic>Methods<\/jats:italic>. In this experiment, db\/db mice were used as an animal model for type 2 diabetic nephropathy. The intervention (QDTS granules and valsartan) started when the mice were 12 weeks old. C57BL\/6 mice were used as normal control. The urine albumin excretion ratio (UAER) was measured by enzyme\u2010linked immunosorbent assay (ELISA) before and after the intervention. The IRS\u20101, PI3K, Akt, and MAPK proteins expression and the phosphorylation levels were detected by western blot. <jats:italic>Results<\/jats:italic>. QDTS granules reduced the 24\u2010h urinary albumin excretion rate (UAE) in db\/db mice with type 2 DM and attenuated the pathological changes of the kidney. QDTS granules also increased the activation level of the PI3K\/Akt signaling pathway and reduced insulin resistance. In addition, QDTS granules inhibited the activation of ERK and p38MAPK and decreased the phosphorylation ratio of Ser307\/Tyr896 of IRS\u20101 in renal tissue. <jats:italic>Conclusions<\/jats:italic>. QDTS granules reduced DM\u2010induced renal injury by improving insulin sensitivity via suppressing MAPK signaling and restoring the phosphorylation balance of tyrosine\/serine of IRS\u20101.<\/jats:p>","DOI":"10.1155\/2018\/2503849","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T13:40:46Z","timestamp":1530538846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["QiDiTangShen Granules Reduced Diabetic Kidney Injury by Regulating the Phosphorylation Balance of the Tyrosine and Serine Residues of Insulin Receptor Substrate 1"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-7761","authenticated-orcid":false,"given":"Xue","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-1580","authenticated-orcid":false,"given":"Hongfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiying","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.04.004"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14090"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3269"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080009"},{"key":"e_1_2_10_5_2","first-page":"S105","volume-title":"Diabetes Care","author":"American Diabetes Association","year":"2018"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/157339911794273883"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.08.015"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.714915"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201219794"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01137"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1323"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-05-0452"},{"key":"e_1_2_10_13_2","first-page":"905","article-title":"Method of combination of disease and syndrome in treating stage iv proteinuria in diabetic nephropathy of qi-yin deficiency","volume":"30","author":"Han Y. 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