{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:33:57Z","timestamp":1783114437690,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":175,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>This study is aimed at investigating the cytotoxicity, anti\u2010inflammatory, and angiogenic activities of two <jats:italic>Boswellia serrata<\/jats:italic> extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of <jats:italic>B. serrata<\/jats:italic> was performed by HPLC using pure boswellic acids (BAs) as standard. In cultured pAECs, extract G improved cell viability, following LPS challenge, in a dose\u2010dependent manner and did not show any toxic effect. On the other hand, extract A was toxic at higher doses and restored pAEC viability after LPS challenge only at lower doses. Pure BAs, used at the same concentrations as those determined in the phytoextracts, did not contrast LPS\u2010induced cytotoxicity. Extract A showed proangiogenic properties at the lowest dose, and the same result was observed using pure AKBA at the corresponding concentration, whereas extract G did not show any effect on the migration capacity of endothelial cells. In conclusion, an anti\u2010inflammatory activity of <jats:italic>B. serrata<\/jats:italic> extracts on endothelial cells was reported, though cytotoxicity or proliferative stimulation can occur instead of a protective effect, depending on the dose and the formulation.<\/jats:p>","DOI":"10.1155\/2018\/2504305","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T23:31:19Z","timestamp":1529969479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Anti\u2010Inflammatory Activity of <i>Boswellia serrata<\/i> Extracts: An <i>In Vitro<\/i> Study on Porcine Aortic Endothelial Cells"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-501X","authenticated-orcid":false,"given":"Martina","family":"Bertocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-8749","authenticated-orcid":false,"given":"Gloria","family":"Isani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Medici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-1952","authenticated-orcid":false,"given":"Giulia","family":"Andreani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-4187","authenticated-orcid":false,"given":"Irvin","family":"Tubon Usca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Roncada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-6202","authenticated-orcid":false,"given":"Monica","family":"Forni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-0244","authenticated-orcid":false,"given":"Chiara","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-11-0075"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0072035"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-018-1129-8"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947227"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41334-1_13"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15802"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.053"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2461"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/11586800-000000000-00000"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1200553"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.03.003"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1235156"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/11263504.2016.1187681"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7468064"},{"key":"e_1_2_8_15_2","first-page":"122","volume-title":"Waste Recovery: Strategies, Techniques and Applications in Europe","author":"Setti L.","year":"2009"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8929-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep15357"},{"key":"e_1_2_8_18_2","unstructured":"BertocchiM. 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