{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:47:57Z","timestamp":1753886877582,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Program of Military Logistic Scientific Research","award":["BWS11J031"],"award-info":[{"award-number":["BWS11J031"]}]},{"DOI":"10.13039\/501100013699","name":"Austrian Federal Ministry of Education, Science and Research","doi-asserted-by":"crossref","award":["BWS11J031"],"award-info":[{"award-number":["BWS11J031"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Eurasia-Pacific Uninet","award":["BWS11J031"],"award-info":[{"award-number":["BWS11J031"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Fluid resuscitation could hardly be performed immediately after fatal hemorrhagic shock in outpatients. We investigated whether electroacupuncture (EA) at Zusanli (ST36) could prevent fatal hemorrhagic shock induced heart failure with delayed fluid resuscitation and whether the protective role of EA is related to the autonomic nervous system. Sixty Sprague Dawley rats were randomly divided into five groups (<jats:italic>n<\/jats:italic> = 12 each): group of sham hemorrhagic shock (SHAM), group of EA, group of sham EA (SEA), group of delayed fluid resuscitation with EA (EA + DR), and group of delayed fluid resuscitation with SEA (SEA + DR). After blood loss for 6 hours, caspase\u20103 activity and positive rate of TUNEL in EA + DR group were significantly lower than in other hemorrhagic shock groups (e.g., versus SEA + DR: 0.156 \u00b1 0.039 versus 0.301 \u00b1 0.042; <jats:italic>P<\/jats:italic> &lt; 0.05). Immediately EA treatment after the blood loss enhanced the protective effect of delayed resuscitation on the cardiac tissue of hemorrhagic shock rats. Considering the significant changes of epinephrine (137.8 \u00b1 6.9\u2009ng\/L versus 98.6 \u00b1 7.4\u2009ng\/L; <jats:italic>P<\/jats:italic> &lt; 0.05) and acetylcholine (405 \u00b1 8.6\u2009pmol\/L versus 341 \u00b1 10.1\u2009pmol\/L; <jats:italic>P<\/jats:italic> &lt; 0.05) after EA treatment (SEA + DR versus EA + DR), this cardiac protective effect may be related to regulation of the autonomic nervous system.<\/jats:p>","DOI":"10.1155\/2018\/2513791","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T23:30:48Z","timestamp":1522711848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heart Protective Effects of Electroacupuncture in an Animal Experimental Study with Delayed Fluid Resuscitation after Hemorrhagic Shock"],"prefix":"10.1155","volume":"2018","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanshi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanqi","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-1491","authenticated-orcid":false,"given":"Yan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-3521","authenticated-orcid":false,"given":"Daniela","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-7108","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-0130","authenticated-orcid":false,"given":"Gerhard","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3779"},{"volume-title":"Student Course Manual","year":"2004","author":"American College of Surgeons","key":"e_1_2_9_2_2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.250.3.R358"},{"key":"e_1_2_9_4_2","first-page":"275","article-title":"Tumor necrosis factor produces homologous desensitization of lymphocyte \u03b22-adrenergic responses","volume":"39","author":"Singh M.","year":"1993","journal-title":"Circulatory Shock"},{"key":"e_1_2_9_5_2","article-title":"Effect of electro-acupuncture at \u2018Zusanli\u2019 (ST 36) on vagal electrical activity in the rat","volume":"31","author":"Ye X. 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