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In this paper, we propose a method for ICA production from ethanol by yeast<jats:italic>Yarrowia lipolytica<\/jats:italic>. The effects of temperature, pH of the medium, and aeration on the growth of the producer<jats:italic>Y. lipolytica<\/jats:italic>VKM Y-2373 and synthesis of ICA were studied. An optimal fermentation regime, which ensures a good growth of the producer and directed synthesis of the target product, was determined. The producer is advised to carry out cultivation at 29\u00b0C and various pH of the medium and the oxygen concentration (pH 5 and pO<jats:sub>2<\/jats:sub>20\u201325% (of saturation) during the growth period and pH 6 and pO<jats:sub>2<\/jats:sub>50\u201355% (of saturation) during the acid formation) on a nutrient medium containing an increased content of zinc (0.6\u2009mg\/L), iron (1.2\u2009mg\/L), and 30\u2009mM itaconic acid (inhibitor of isocitrate lyase\u2014the key enzyme of ICA metabolism) should also be introduced into the nutrition medium. Such fermentation production mode provides 90.5\u2009g\/L ICA with process selectivity of 80%, mass yield (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>Y<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">I<\/mml:mi><mml:mi mathvariant=\"normal\">C<\/mml:mi><mml:mi mathvariant=\"normal\">A<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>) of 0.77\u2009g\/g, and energy yield (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">I<\/mml:mi><mml:mi mathvariant=\"normal\">C<\/mml:mi><mml:mi mathvariant=\"normal\">A<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>) of 0.278\u2009g\/g.<\/jats:p>","DOI":"10.1155\/2018\/2543210","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T23:30:52Z","timestamp":1518046252000},"page":"1-9","source":"Crossref","is-referenced-by-count":32,"title":["Fermentation Conditions and Media Optimization for Isocitric Acid Production from Ethanol by<i>Yarrowia lipolytica<\/i>"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-2345","authenticated-orcid":true,"given":"Svetlana V.","family":"Kamzolova","sequence":"first","affiliation":[{"name":"G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr-t Nauki 5, P.O. Box 142290, Pushchino, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman V.","family":"Shamin","sequence":"additional","affiliation":[{"name":"Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, P.O. Box 117198, Moscow, Russia"},{"name":"Moscow Technological University (MIREA), Vernadskogo Pr. 78, P.O. Box 119454, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda N.","family":"Stepanova","sequence":"additional","affiliation":[{"name":"G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr-t Nauki 5, P.O. Box 142290, Pushchino, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorii I.","family":"Morgunov","sequence":"additional","affiliation":[{"name":"Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, P.O. Box 117198, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia N.","family":"Lunina","sequence":"additional","affiliation":[{"name":"G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr-t Nauki 5, P.O. Box 142290, Pushchino, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramil K.","family":"Allayarov","sequence":"additional","affiliation":[{"name":"G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr-t Nauki 5, P.O. 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