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Treatments for gout pain are limited to colchicine, nonsteroidal anti\u2010inflammatory drugs, and corticosteroids, which oftentimes result in severe adverse effects. Electroacupuncture (EA) has been proved to be effective in relieving many inflammatory pain conditions with few side effects. Here, we aim to investigate the therapeutic potentials of EA on pain and inflammation of a rat model of acute gout arthritis and underlying mechanisms. We found that 2\/100\u2009Hz EA produced the most robust analgesic effect on mechanical hyperalgesia of acute gout arthritis rat model compared with 2 and 100\u2009Hz. EA produced similar analgesic effect compared with indomethacin. 2\/100\u2009Hz EA also significantly alleviates the ongoing pain behavior, thermal hyperalgesia, and ankle edema. Locally applied <jats:italic>\u03bc<\/jats:italic> and <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor antagonists but not adenosine A<jats:sub>1<\/jats:sub> receptor antagonist significantly abolished the analgesic effect of EA. Locally applied <jats:italic>\u03bc<\/jats:italic> and <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor agonists produced significant antiallodynia on acute gout arthritis rats, mimicking EA. Furthermore, 2\/100\u2009Hz EA upregulated <jats:italic>\u03b2<\/jats:italic>\u2010endorphin expression in inflamed ankle skin tissue. Our results demonstrated, for the first time, that EA can be used for relieving acute gout arthritis with effect dependent on peripheral opioid system and comparable with the one obtained with indomethacin.<\/jats:p>","DOI":"10.1155\/2018\/2598975","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T23:30:34Z","timestamp":1521502234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Wenxin","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-1178","authenticated-orcid":false,"given":"Xiaomei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-5696","authenticated-orcid":false,"given":"Guo-qing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-5130","authenticated-orcid":false,"given":"Jianqiao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-4548","authenticated-orcid":false,"given":"Boyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.236"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030733"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3199"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-1-54"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh640"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3485875"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000101"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3632168"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-9-13"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.06.004"},{"key":"e_1_2_9_11_2","article-title":"Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine","volume":"7","author":"Yen L. 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