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In this study, murine iPSC underwent differentiation towards an MSC-like immunophenotype. Stable miPSC-MSC cultures expressed the MSC-associated markers, CD73, CD105, and Sca-1, but lacked expression of the pluripotency marker, SSEA1, and hematopoietic markers, CD34 and CD45. Functionally, miPSC-MSC exhibited the potential for trilineage differentiation into osteoblasts, adipocytes, and chondrocytes and the capacity to suppress the proliferation of mitogen-activated splenocytes. The efficacy of miPSC-MSC was assessed in an acute inflammation model following systemic or local delivery into mice with subcutaneous implants containing heat-inactivated\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>gingivalis<\/jats:italic>\n                    . Histological analysis revealed less inflammatory cellular infiltrate within the sponges in mice treated with miPSC-MSC cells delivered locally rather than systemically. Assessment of proinflammatory cytokines in mouse spleens found that CXCL1 transcripts and protein were reduced in mice treated with miPSC-MSC. In a periodontitis model, mice subjected to oral inoculation with\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>gingivalis<\/jats:italic>\n                    revealed less bone tissue destruction and inflammation within the jaws when treated with miPSC-MSC compared to PBS alone. Our results demonstrated that miPSC-MSC derived from iPSC have the capacity to control acute and chronic inflammatory responses associated with the destruction of periodontal tissue. Therefore, miPSC-MSC present a promising novel source of stromal cells which could be used in the treatment of periodontal disease and other inflammatory systemic diseases such as rheumatoid arthritis.\n                  <\/jats:p>","DOI":"10.1155\/2018\/2601945","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T19:30:51Z","timestamp":1521055851000},"page":"1-12","source":"Crossref","is-referenced-by-count":22,"title":["Potential of iPSC-Derived Mesenchymal Stromal Cells for Treating Periodontal Disease"],"prefix":"10.1155","volume":"2018","author":[{"given":"K.","family":"Hynes","sequence":"first","affiliation":[{"name":"Department of Dentistry, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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