{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:32:55Z","timestamp":1779928375864,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}]},{"name":"National High Technology Research and Development Program of China","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}]},{"name":"National High Technology Research and Development Program of China","award":["81301247"],"award-info":[{"award-number":["81301247"]}]},{"name":"National High Technology Research and Development Program of China","award":["81501528"],"award-info":[{"award-number":["81501528"]}]},{"name":"National High Technology Research and Development Program of China","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}]},{"name":"National High Technology Research and Development Program of China","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}]},{"name":"National High Technology Research and Development Program of China","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"crossref","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["2007AA02Z471"],"award-info":[{"award-number":["2007AA02Z471"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["2017YFA0103201"],"award-info":[{"award-number":["2017YFA0103201"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["81301247"],"award-info":[{"award-number":["81301247"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["81501528"],"award-info":[{"award-number":["81501528"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["BK20130082"],"award-info":[{"award-number":["BK20130082"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["QNRC2016075"],"award-info":[{"award-number":["QNRC2016075"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["15JCQNJC10600"],"award-info":[{"award-number":["15JCQNJC10600"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:sup>32<\/jats:sup>P high-dose rate brachytherapy allows high-dose radiation delivery to target lesions with less damage to adjacent tissues. The early evaluation of its therapeutic effect on tumours is vital for the optimization of treatment regimes. The most commonly used <jats:sup>32<\/jats:sup>P-CP colloid tends to leak with blind therapeutic area after intratumour injection. We prepared <jats:sup>32<\/jats:sup>P-chromic phosphate-polylactide-co-glycolide (<jats:sup>32<\/jats:sup>P-CP-PLGA) seeds with biodegradable PLGA as a framework and investigated their characteristics<jats:italic> in vitro<\/jats:italic> and<jats:italic> in vivo<\/jats:italic>. We also evaluated the therapeutic effect of <jats:sup>32<\/jats:sup>P-CP-PLGA brachytherapy for glioma with the integrin <jats:italic>\u03b1<\/jats:italic>v<jats:italic>\u03b2<\/jats:italic>3-targeted radiotracer <jats:sup>68<\/jats:sup>Ga-3PRGD<jats:sub>2<\/jats:sub>. <jats:sup>32<\/jats:sup>P-CP-PLGA seeds (seed group, SG, 185\u2009MBq) and <jats:sup>32<\/jats:sup>P-CP colloid (colloid group, CG, 18.5\u2009MBq) were implanted or injected into human glioma xenografts in nude mice. Scanning electron microscopy (SEM) of the seeds, micro-SPECT imaging, and biodistribution studies were performed at different time points. The tumour volume was measured using a caliper, and <jats:sup>68<\/jats:sup>Ga-3PRGD<jats:sub>2<\/jats:sub> micro-PET-CT imaging was performed to evaluate the therapeutic effect after <jats:sup>32<\/jats:sup>P intratumour administration. The delayed release of <jats:sup>32<\/jats:sup>P-CP was observed with biodegradation of vehicle PLGA. Intratumoural effective half-life of <jats:sup>32<\/jats:sup>P-CP in the SG (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">13.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.3<\/mml:mn><\/mml:math>)\u2009d was longer than that in the CG (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">10.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.3<\/mml:mn><\/mml:math>)\u2009d (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), with liver appearance in the CG on SPECT. A radioactivity gradient developed inside the tumour in the SG, as confirmed by micro-SPECT and SEM. Tumour uptake of <jats:sup>68<\/jats:sup>Ga-3PRGD<jats:sub>2<\/jats:sub> displayed a significant increase on day 0.5 in the SG and decreased earlier (on day 2) than the volume reduction (on day 8). Thus, <jats:sup>32<\/jats:sup>P-CP-PLGA seeds, controlling the release of entrapped <jats:sup>32<\/jats:sup>P-CP particles, are promising for glioma brachytherapy, and <jats:sup>68<\/jats:sup>Ga-3PRGD<jats:sub>2<\/jats:sub> imaging shows potential for early response evaluation of <jats:sup>32<\/jats:sup>P-CP-PLGA seeds brachytherapy.<\/jats:p>","DOI":"10.1155\/2018\/2630480","type":"journal-article","created":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T23:31:00Z","timestamp":1525044660000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of Newly Prepared Biodegradable <sup>32<\/sup>P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy"],"prefix":"10.1155","volume":"2018","author":[{"given":"Guoqiang","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-0788","authenticated-orcid":true,"given":"Yuebing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Bayi Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Invasive Technology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Southeast University, Nanjing 210000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-3095","authenticated-orcid":true,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-5326","authenticated-orcid":true,"given":"Zizheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1066-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not126"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2007.08.004"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.5079"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31826d5ac1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2451-6"},{"issue":"4 c","key":"7","first-page":"2997","volume":"27","year":"2007","journal-title":"Anticancer Reseach"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025447128887"},{"key":"9","first-page":"958","volume":"37","year":"1996","journal-title":"Society of Nuclear Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.06.022"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.926574"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cossms.2013.01.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2011.1141"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1615\/critrevtherdrugcarriersyst.v21.i5.20"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.05.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1021\/mp5003224"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00169"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1021\/mp5003202"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.080606"},{"key":"20","first-page":"39","year":"2013","journal-title":"12"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0047-0740(85)90028-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.11133"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1639"}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/2630480.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/2630480.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2018\/2630480.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:08:25Z","timestamp":1589886505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmi\/2018\/2630480\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":23,"alternative-id":["2630480","2630480"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2630480","relation":{},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"value":"1555-4309","type":"print"},{"value":"1555-4317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}