{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:22:58Z","timestamp":1785039778069,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009051","name":"Universidad T\u00e9cnica Federico Santa Mar\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Currently, the most effective treatment for recurrent urinary tract infections in women is antibiotics. However, the limitation for this treatment is the duration and dosage of antibiotics and the resistance that bacteria develop after a long period of administration. With the aim of identifying mainly novel natural agents with antibacterial activity, the present study was undertaken to investigate the biological and phytochemical properties of extracts from the leaves <jats:italic>Taraxacum officinale.<\/jats:italic> The structural identification of compounds present in hexane (Hex) and ethyl acetate (AcOEt) extracts was performed by mass spectrometry (GC\u2010MS) spectroscopic techniques and nuclear magnetic resonance (NMR) with the major compounds corresponding to different sesquiterpene lactones (<jats:italic>\u03b1<\/jats:italic>\u2010santonin, glabellin, arborescin, and estafiatin), monoterpene (9,10\u2010dimethyltricycle [4.2.1.1 (2,5)]decane\u20109,10\u2010diol), phytosterol (Stigmasta\u20105,22\u2010dien\u20103<jats:italic>\u03b2<\/jats:italic>\u2010ol acetate), terpenes (lupeol acetate, pregn\u20105\u2010en\u201020\u2010one\u20103<jats:italic>\u03b2<\/jats:italic>\u2010acetyloxy\u201017\u2010hydroxy, 2\u2010hydroxy\u20104\u2010methoxy benzaldehyde), and coumarin (benzofuranone 5,6,7,7\u2010a\u2010tetraaldehyde\u20104,4,7a\u2010trimethyl). The results obtained show that the Hex extract was highly active against <jats:italic>Staphylococcus aureus<\/jats:italic> showing a MIC of 200\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and moderately active against <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> with MIC values of 400\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 800\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL for the other Gram\u2010negative strains tested with <jats:italic>Proteus mirabilis<\/jats:italic> as uropathogens <jats:italic>in vitro<\/jats:italic>. Therefore, the effective dandelion extracts could be used in the development of future products with industrial application.<\/jats:p>","DOI":"10.1155\/2018\/2706417","type":"journal-article","created":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T23:30:25Z","timestamp":1514849425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Isolation and Identification of Compounds from Bioactive Extracts of <i>Taraxacum officinale<\/i> Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-1123","authenticated-orcid":false,"given":"Katy","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Madrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-9536","authenticated-orcid":false,"given":"Rolando","family":"Chamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-013-0317-5"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4141\/P01-010"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00509.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.07.021"},{"key":"e_1_2_8_5_2","first-page":"71","article-title":"Clinical study of 96 cases with chronic hepatitis B treated with jiedu yanggan gao by a double-blind method","volume":"10","author":"Chen Z.","year":"1990","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.035"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-91992010000300006"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612780"},{"key":"e_1_2_8_9_2","first-page":"1","article-title":"Qualitative and quantitative analysis of phytochemicals of Taraxacum officinale","volume":"2","author":"Mir M.","year":"2013","journal-title":"Wudpecker Journal of Pharmacy and Pharmacology"},{"key":"e_1_2_8_10_2","first-page":"17","article-title":"Terpenoids from Taraxacum officinale","volume":"10","author":"Ragasa C.","year":"2009","journal-title":"National Research Council of the Philippines Research Journal"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-05722011000200009"},{"key":"e_1_2_8_12_2","first-page":"4665","article-title":"Antimicrobial activity of selected medicinal plants of Margalla hills, Islamabad, Pakistan","volume":"5","author":"Khan A. M.","year":"2011","journal-title":"Journal of Medicinal Plant Research"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR11.869"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.22401\/JNUS.15.3.02"},{"key":"e_1_2_8_15_2","first-page":"1","article-title":"Screening ethanolic and aqueous leaf extracts of Taraxacum offinale for in vitro bacteria growth inhibition","volume":"20","author":"Lateef O.","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Sciences Vol"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2013.3518"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.03.126"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2014.40309"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.22146\/ijc.21422"},{"key":"e_1_2_8_20_2","first-page":"346","article-title":"Actividad antiviral contra el virus de la fiebre amarilla, cepa vacunal 17D, de extractos de hojas de Taraxacum officinale GH Weber ex Wiggers","volume":"12","author":"Rodr\u00edguez-Ortega M.","year":"2013","journal-title":"Bolet\u00edn Latinoamericano y del Caribe de Plantas Medicinales y Arom\u00e1ticas"},{"key":"e_1_2_8_21_2","first-page":"125","article-title":"Two triterpenes lupanone and lupeol isolated and identified from Tamarindus indica linn.","volume":"20","author":"Imam S.","year":"2007","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89569-2"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2005000300002"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2013.10.026"},{"key":"e_1_2_8_25_2","first-page":"17","article-title":"Terpenoids from Taraxacum officinale","volume":"10","author":"Ragasa C.","year":"2009","journal-title":"National Research Council of the Philippines Research Journal"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2007000200012"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422011000400026"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.3329\/icpj.v1i9.11613"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.3923\/ijbc.2012.130.135"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ed084p1985"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v11i2.12"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.12.001"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091121"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/0005772X.2001.11099504"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.59.1309"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4522.2002.tb00209.x"},{"key":"e_1_2_8_37_2","unstructured":"USDA National Nutrient Database for Standard Reference Release 28 slightly revised May 2016. Software v.3.7 2017-02-01. Online document at:https:\/\/www.ars.usda.gov."},{"key":"e_1_2_8_38_2","first-page":"113","article-title":"Antimicrobial activity of some hydroalcoholic extracts of artichoke (cynara scolymus), burdock (arctium lappa) and dandelion (taraxacum officinale)","volume":"6","author":"Ionescu D.","year":"2013","journal-title":"Bulletin of the Transilvania University of Brasov, Series II: Forestry, Wood Industry, Agricultural Food Engineering"},{"key":"e_1_2_8_39_2","first-page":"62","article-title":"Study of Some Eucalptus Rostrata Leaves Components and Effect of Its Extract on Different Microorganisms","volume":"16","author":"Jassim A. M. N.","year":"2005","journal-title":"Al-Mustansiriyah Journal of Science"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2003.12.012"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111441"},{"key":"e_1_2_8_42_2","unstructured":"NIST\/EPA\/NIH Mass Spectral Library with Search Program (Data Version: NIST 11 Software Version 2.0 g).http:\/\/webbook.nist.gov\/chemistry\/name-ser.html."},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-012-0998-z"},{"key":"e_1_2_8_44_2","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams R. P.","year":"2007"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.45-0723"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.suppl_1.5"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/2706417.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/2706417.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/2706417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T05:23:11Z","timestamp":1722921791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/2706417"}},"subtitle":[],"editor":[{"given":"Gianni","family":"Sacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/2706417"],"URL":"https:\/\/doi.org\/10.1155\/2018\/2706417","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2706417"}}